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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

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Score

Score

Score

Antibodies

Column

 
 
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TM4SF4
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    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

TM4SF4

Gene description

Transmembrane 4 L six family member 4

Protein class

Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (duodenum, gallbladder, liver, small intestine)
GTEx:Group enriched (liver, pancreas, small intestine)
FANTOM5:Tissue enhanced (colon, gallbladder, small intestine)

Protein evidence

Evidence at protein level

Protein expression

Membranous expression mainly in liver, gallbladder, duodenum and small intestine

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA046430
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (duodenum, gallbladder, liver, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, pancreas, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, gallbladder, small intestine)

GENE INFORMATION

Gene name

TM4SF4 (HGNC Symbol)

Synonyms

il-TMP

Description

Transmembrane 4 L six family member 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]

Chromosome

3

Cytoband

q25.1

Chromosome location (bp)

149473974 - 149503281

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169903 (version 83.38)

Entrez gene

7104

UniProt

P48230 (UniProt - Evidence at protein level)

neXtProt

NX_P48230

Antibodypedia

TM4SF4 antibodies

PROTEIN BROWSER

TM4SF4-001
TM4SF4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TM4SF4-001
ENSP00000305852
ENST00000305354
P48230 [Direct mapping]
Transmembrane 4 L6 family member 4
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
GO:0042246 [tissue regeneration]
Show all
202 aa
21.4 kDa
No 4
TM4SF4-002
ENSP00000419367
ENST00000465758
C9JVD2 [Direct mapping]
Transmembrane 4 L6 family member 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0016021 [integral component of membrane]
Show all
81 aa
8.5 kDa
No 2

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