Expression of ARL6IP1 in cancer - Summary - The Human Protein Atlas

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ARL6IP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ARL6IP1
Gene description	ADP-ribosylation factor-like 6 interacting protein 1
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA045307
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045307

GENE INFORMATION
Gene name	ARL6IP1 (HGNC Symbol)
Synonyms	AIP1, ARL6IP, ARMER, KIAA0069, SPG61
Description	ADP-ribosylation factor-like 6 interacting protein 1 (HGNC Symbol)
Entrez gene summary	This gene belongs to the ARL6ip family and encodes a transmembrane protein that is predominantly localized to intracytoplasmic membranes. It is highly expressed in early myeloid progenitor cells and thought to be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Mutations in this gene are associated with spastic paraplegia 61 (SPG61). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
Chromosome	16
Cytoband	p12.3
Chromosome location (bp)	18791667 - 18801678
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170540 (version 83.38)
Entrez gene	23204
UniProt	Q15041 (UniProt - Evidence at protein level)
neXtProt	NX_Q15041
Antibodypedia	ARL6IP1 antibodies

PROTEIN BROWSER

ARL6IP1-001	ARL6IP1-002	ARL6IP1-006	ARL6IP1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARL6IP1-001 ENSP00000306788 ENST00000304414	Q15041 [Direct mapping] ADP-ribosylation factor-like protein 6-interacting protein 1 A0A024QYV7 [Target identity:100%; Query identity:100%] HCG1994130, isoform CRA_c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005784 [Sec61 translocon complex] GO:0005829 [cytosol] GO:0006613 [cotranslational protein targeting to membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	203 aa 23.4 kDa	No	5
ARL6IP1-002 ENSP00000440048 ENST00000546206	Q15041 [Direct mapping] ADP-ribosylation factor-like protein 6-interacting protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Show all	GO:0005515 [protein binding] GO:0005784 [Sec61 translocon complex] GO:0006613 [cotranslational protein targeting to membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	174 aa 20.3 kDa	No	6
ARL6IP1-006 ENSP00000455341 ENST00000562234	H3BPJ2 [Direct mapping] ADP-ribosylation factor-like protein 6-interacting protein 1 Show all	Predicted intracellular proteins Show all		101 aa 12 kDa	No	0
ARL6IP1-008 ENSP00000457372 ENST00000562819	H3BTX6 [Direct mapping] ADP-ribosylation factor-like protein 6-interacting protein 1 Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Show all	GO:0016021 [integral component of membrane] Show all	88 aa 10 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.