Most cancer cells showed weak to moderate cytoplasmic positivity. Additional membranous staining was observed in many pancreatic cancers. Several carcinoids, lymphomas and renal cancers were negative.
ARL6IP1 (HGNC Symbol)
AIP1, ARL6IP, ARMER, KIAA0069, SPG61
ADP-ribosylation factor-like 6 interacting protein 1 (HGNC Symbol)
Entrez gene summary
This gene belongs to the ARL6ip family and encodes a transmembrane protein that is predominantly localized to intracytoplasmic membranes. It is highly expressed in early myeloid progenitor cells and thought to be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Mutations in this gene are associated with spastic paraplegia 61 (SPG61). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]