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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

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Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

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Score

Score

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Antibodies

Column

 
 
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ARL6IP1
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ARL6IP1

Gene description

ADP-ribosylation factor-like 6 interacting protein 1

Protein class

Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA045307
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

ARL6IP1 (HGNC Symbol)

Synonyms

AIP1, ARL6IP, ARMER, KIAA0069, SPG61

Description

ADP-ribosylation factor-like 6 interacting protein 1 (HGNC Symbol)

Entrez gene summary

This gene belongs to the ARL6ip family and encodes a transmembrane protein that is predominantly localized to intracytoplasmic membranes. It is highly expressed in early myeloid progenitor cells and thought to be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation. Mutations in this gene are associated with spastic paraplegia 61 (SPG61). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]

Chromosome

16

Cytoband

p12.3

Chromosome location (bp)

18791667 - 18801678

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170540 (version 83.38)

Entrez gene

23204

UniProt

Q15041 (UniProt - Evidence at protein level)

neXtProt

NX_Q15041

Antibodypedia

ARL6IP1 antibodies

PROTEIN BROWSER

ARL6IP1-001
ARL6IP1-002
ARL6IP1-006
ARL6IP1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARL6IP1-001
ENSP00000306788
ENST00000304414
Q15041 [Direct mapping]
ADP-ribosylation factor-like protein 6-interacting protein 1
A0A024QYV7 [Target identity:100%; Query identity:100%]
HCG1994130, isoform CRA_c
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005784 [Sec61 translocon complex]
GO:0005829 [cytosol]
GO:0006613 [cotranslational protein targeting to membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
203 aa
23.4 kDa
No 5
ARL6IP1-002
ENSP00000440048
ENST00000546206
Q15041 [Direct mapping]
ADP-ribosylation factor-like protein 6-interacting protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
Show all
GO:0005515 [protein binding]
GO:0005784 [Sec61 translocon complex]
GO:0006613 [cotranslational protein targeting to membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
174 aa
20.3 kDa
No 6
ARL6IP1-006
ENSP00000455341
ENST00000562234
H3BPJ2 [Direct mapping]
ADP-ribosylation factor-like protein 6-interacting protein 1
Show all
Predicted intracellular proteins
Show all
101 aa
12 kDa
No 0
ARL6IP1-008
ENSP00000457372
ENST00000562819
H3BTX6 [Direct mapping]
ADP-ribosylation factor-like protein 6-interacting protein 1
Show all
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0016021 [integral component of membrane]
Show all
88 aa
10 kDa
No 0

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