Cell atlas - PGAM1 - The Human Protein Atlas

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PGAM1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PGAM1
Gene description	Phosphoglycerate mutase 1 (brain)
Protein class	Candidate cardiovascular disease genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA042528 , HPA060483
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA042528	CACO-2	Nucleoplasm
	HPA042528	PC-3	Nucleoplasm
	HPA060483	Hep G2	Nucleoplasm
	HPA060483	PC-3	Nucleoplasm
	HPA060483	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	PGAM1 (HGNC Symbol)
Synonyms	PGAM-B, PGAMA
Description	Phosphoglycerate mutase 1 (brain) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Chromosome	10
Cytoband	q24.1
Chromosome location (bp)	97426160 - 97433441
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171314 (version 83.38)
Entrez gene	5223
UniProt	P18669 (UniProt - Evidence at protein level)
neXtProt	NX_P18669
Antibodypedia	PGAM1 antibodies

PROTEIN BROWSER

PGAM1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PGAM1-001 ENSP00000359991 ENST00000334828	P18669 [Direct mapping] Phosphoglycerate mutase 1 Q6FHU2 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 35; HCG2015269, isoform CRA_a; PGAM1 protein; Phosphoglycerate mutase 1 (Brain); Phosphoglycerate mutase 1 (Brain), isoform CRA_b; cDNA FLJ77692, highly similar to Homo sapiens phosphoglycerate mutase 1 (brain) (PGAM1), mRNA; cDNA FLJ78401, highly similar to Homo sapiens phosphoglycerate mutase 1 (brain) (PGAM1), mRNA; cDNA, FLJ92670, Homo sapiens phosphoglycerate mutase 1 (brain) (PGAM1), mRNA Show all	Enzymes ENZYME proteins Hydrolases Isomerase Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004082 [bisphosphoglycerate mutase activity] GO:0004083 [bisphosphoglycerate 2-phosphatase activity] GO:0004619 [phosphoglycerate mutase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006096 [glycolytic process] GO:0006110 [regulation of glycolytic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016311 [dephosphorylation] GO:0016868 [intramolecular transferase activity, phosphotransferases] GO:0019901 [protein kinase binding] GO:0043456 [regulation of pentose-phosphate shunt] GO:0044281 [small molecule metabolic process] GO:0045730 [respiratory burst] GO:0046538 [2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity] GO:0061621 [canonical glycolysis] GO:0070062 [extracellular exosome] Show all	254 aa 28.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.