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PGAM1

GENERAL INFORMATION

Gene name

 PGAM1

Gene description

 Phosphoglycerate mutase 1 (brain)

Protein class

 Candidate cardiovascular disease genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 2 antibodies.
HPA042528 , HPA049237
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PGAM1 (HGNC Symbol)

Synonyms

 PGAM-B, PGAMA

Description

 Phosphoglycerate mutase 1 (brain) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Chromosome

 10

Cytoband

 q24.1

Chromosome location (bp)

 97426160 - 97433441

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171314 (version 83.38)

Entrez gene

 5223

UniProt

 P18669 (UniProt - Evidence at protein level)

neXtProt

 NX_P18669

Antibodypedia

 PGAM1 antibodies

PROTEIN BROWSER
PGAM1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PGAM1-001
ENSP00000359991
ENST00000334828
P18669 [Direct mapping]
Phosphoglycerate mutase 1
Q6FHU2 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 35; HCG2015269, isoform CRA_a; PGAM1 protein; Phosphoglycerate mutase 1 (Brain); Phosphoglycerate mutase 1 (Brain), isoform CRA_b; cDNA FLJ77692, highly similar to Homo sapiens phosphoglycerate mutase 1 (brain) (PGAM1), mRNA; cDNA FLJ78401, highly similar to Homo sapiens phosphoglycerate mutase 1 (brain) (PGAM1), mRNA; cDNA, FLJ92670, Homo sapiens phosphoglycerate mutase 1 (brain) (PGAM1), mRNA
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Enzymes
   ENZYME proteins
   Hydrolases
   Isomerase
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004082 [bisphosphoglycerate mutase activity]
GO:0004083 [bisphosphoglycerate 2-phosphatase activity]
GO:0004619 [phosphoglycerate mutase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006110 [regulation of glycolytic process]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016311 [dephosphorylation]
GO:0016868 [intramolecular transferase activity, phosphotransferases]
GO:0019901 [protein kinase binding]
GO:0043456 [regulation of pentose-phosphate shunt]
GO:0044281 [small molecule metabolic process]
GO:0045730 [respiratory burst]
GO:0046538 [2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
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 254 aa
28.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.