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LGALS4

GENERAL INFORMATION

Gene name

 LGALS4

Gene description

 Lectin, galactoside-binding, soluble, 4

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (colorectal cancer, liver cancer, pancreatic cancer, stomach cancer)
HPA (cell line):Cell line enhanced (RT4)
HPA (normal tissue):Tissue enhanced (colon, duodenum, rectum, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct cytoplasmic expression in gastrointestinal tract and gall bladder.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA031184 , HPA031185 , HPA031186 , CAB025653
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (colorectal cancer, liver cancer, pancreatic cancer, stomach cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA031184
HPA031185
HPA031186
CAB025653

GENE INFORMATION

Gene name

 LGALS4 (HGNC Symbol)

Synonyms

 GAL4

Description

 Lectin, galactoside-binding, soluble, 4 (HGNC Symbol)

Entrez gene summary

 The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 38801671 - 38813364

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171747 (version 83.38)

Entrez gene

 3960

UniProt

 P56470 (UniProt - Evidence at protein level)

neXtProt

 NX_P56470

Antibodypedia

 LGALS4 antibodies

PROTEIN BROWSER
LGALS4-001
LGALS4-004
LGALS4-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LGALS4-001
ENSP00000302100
ENST00000307751
P56470 [Direct mapping]
Galectin-4
Q6FHZ4 [Target identity:100%; Query identity:100%]
Galectin
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0016936 [galactoside binding]
GO:0030246 [carbohydrate binding]
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 323 aa
35.9 kDa 		No 0
LGALS4-004
ENSP00000472990
ENST00000594209
M0R349 [Direct mapping]
Galectin-4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0030246 [carbohydrate binding]
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 31 aa
3.4 kDa 		No 0
LGALS4-007
ENSP00000470387
ENST00000600070
M0QZ93 [Direct mapping]
Galectin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0030246 [carbohydrate binding]
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 218 aa
24.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.