Tissue expression of LGALS4 - Summary - The Human Protein Atlas

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LGALS4

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	LGALS4
Gene description	Lectin, galactoside-binding, soluble, 4
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (colon, duodenum, rectum, small intestine)
GTEx:	Group enriched (colon, small intestine)
FANTOM5:	Group enriched (appendix, colon, gallbladder, small intestine)

Protein evidence

Evidence at protein level

Protein expression

Distinct cytoplasmic expression in gastrointestinal tract and gall bladder.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 4 antibodies. HPA031184 , HPA031185 , HPA031186 , CAB025653
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (colon, duodenum, rectum, small intestine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (colon, small intestine)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (appendix, colon, gallbladder, small intestine)

GENE INFORMATION
Gene name	LGALS4 (HGNC Symbol)
Synonyms	GAL4
Description	Lectin, galactoside-binding, soluble, 4 (HGNC Symbol)
Entrez gene summary	The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	38801671 - 38813364
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171747 (version 83.38)
Entrez gene	3960
UniProt	P56470 (UniProt - Evidence at protein level)
neXtProt	NX_P56470
Antibodypedia	LGALS4 antibodies

PROTEIN BROWSER

LGALS4-001	LGALS4-004	LGALS4-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LGALS4-001 ENSP00000302100 ENST00000307751	P56470 [Direct mapping] Galectin-4 Q6FHZ4 [Target identity:100%; Query identity:100%] Galectin Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0016936 [galactoside binding] GO:0030246 [carbohydrate binding] Show all	323 aa 35.9 kDa	No	0
LGALS4-004 ENSP00000472990 ENST00000594209	M0R349 [Direct mapping] Galectin-4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030246 [carbohydrate binding] Show all	31 aa 3.4 kDa	No	0
LGALS4-007 ENSP00000470387 ENST00000600070	M0QZ93 [Direct mapping] Galectin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030246 [carbohydrate binding] Show all	218 aa 24.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.