Cell atlas - CTPS1 - The Human Protein Atlas

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CTPS1

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Cytosol

Human cell
	Actin Filaments
	Cytosol

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GENERAL INFORMATION
Gene name	CTPS1
Gene description	CTP synthase 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & actin filaments.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Actin filaments (supported), Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. CAB017111 , HPA051322
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & actin filaments.

Main location

Actin filaments (supported), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB017111	A-431	Cytosol
	CAB017111	U-2 OS	Cytosol
	CAB017111	U-251 MG	Cytosol
	HPA051322	A-431	Actin filaments
	HPA051322	A-431	Cytosol
	HPA051322	U-2 OS	Actin filaments
	HPA051322	U-2 OS	Cytosol
	HPA051322	U-251 MG	Plasma membrane
			Actin filaments
			Cytosol

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000028633 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA051322	NIH 3T3	Plasma membrane
	HPA051322	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	CTPS1 (HGNC Symbol)
Synonyms	CTPS
Description	CTP synthase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	1
Cytoband	p34.2
Chromosome location (bp)	40979335 - 41012565
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171793 (version 83.38)
Entrez gene	1503
UniProt	P17812 (UniProt - Evidence at protein level)
neXtProt	NX_P17812
Antibodypedia	CTPS1 antibodies

PROTEIN BROWSER

CTPS1-001	CTPS1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTPS1-001 ENSP00000361704 ENST00000372621	P17812 [Direct mapping] CTP synthase 1 Show all	Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003883 [CTP synthase activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006221 [pyrimidine nucleotide biosynthetic process] GO:0006241 [CTP biosynthetic process] GO:0006541 [glutamine metabolic process] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0016020 [membrane] GO:0042098 [T cell proliferation] GO:0042100 [B cell proliferation] GO:0042493 [response to drug] GO:0044210 ['de novo' CTP biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	591 aa 66.7 kDa	No	0
CTPS1-002 ENSP00000361699 ENST00000372616	P17812 [Direct mapping] CTP synthase 1 Show all	Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003883 [CTP synthase activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006221 [pyrimidine nucleotide biosynthetic process] GO:0006241 [CTP biosynthetic process] GO:0006541 [glutamine metabolic process] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0016020 [membrane] GO:0042098 [T cell proliferation] GO:0042100 [B cell proliferation] GO:0042493 [response to drug] GO:0044210 ['de novo' CTP biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	591 aa 66.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.