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CTPS1

GENERAL INFORMATION

Gene name

 CTPS1

Gene description

 CTP synthase 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB017111
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CTPS1 (HGNC Symbol)

Synonyms

 CTPS

Description

 CTP synthase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 1

Cytoband

 p34.2

Chromosome location (bp)

 40979335 - 41012565

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000171793 (version 83.38)

Entrez gene

 1503

UniProt

 P17812 (UniProt - Evidence at protein level)

neXtProt

 NX_P17812

Antibodypedia

 CTPS1 antibodies

PROTEIN BROWSER
CTPS1-001
CTPS1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTPS1-001
ENSP00000361704
ENST00000372621
P17812 [Direct mapping]
CTP synthase 1
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Enzymes
   ENZYME proteins
   Ligase
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003883 [CTP synthase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006221 [pyrimidine nucleotide biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0006541 [glutamine metabolic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0016020 [membrane]
GO:0042098 [T cell proliferation]
GO:0042100 [B cell proliferation]
GO:0042493 [response to drug]
GO:0044210 ['de novo' CTP biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 591 aa
66.7 kDa 		No 0
CTPS1-002
ENSP00000361699
ENST00000372616
P17812 [Direct mapping]
CTP synthase 1
Show all
Enzymes
   ENZYME proteins
   Ligase
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003883 [CTP synthase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006221 [pyrimidine nucleotide biosynthetic process]
GO:0006241 [CTP biosynthetic process]
GO:0006541 [glutamine metabolic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0016020 [membrane]
GO:0042098 [T cell proliferation]
GO:0042100 [B cell proliferation]
GO:0042493 [response to drug]
GO:0044210 ['de novo' CTP biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 591 aa
66.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.