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GAP43

GENERAL INFORMATION

Gene name

 GAP43

Gene description

 Growth associated protein 43

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Group enriched (AF22, NTERA-2, SCLC-21H, SH-SY5Y, U-87 MG)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in the CNS and peripheral nerves.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA013392 , HPA015600 , CAB004417
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA013392
HPA015600
CAB004417

GENE INFORMATION

Gene name

 GAP43 (HGNC Symbol)

Synonyms

 B-50, PP46

Description

 Growth associated protein 43 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q13.31

Chromosome location (bp)

 115623324 - 115721490

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172020 (version 83.38)

Entrez gene

 2596

UniProt

 P17677 (UniProt - Evidence at protein level)

neXtProt

 NX_P17677

Antibodypedia

 GAP43 antibodies

PROTEIN BROWSER
GAP43-001
GAP43-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GAP43-001
ENSP00000305010
ENST00000305124
P17677 [Direct mapping]
Neuromodulin
Q5U058 [Target identity:100%; Query identity:100%]
Growth associated protein 43; cDNA, FLJ94238, Homo sapiens growth associated protein 43 (GAP43), mRNA
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0009611 [response to wounding]
GO:0014069 [postsynaptic density]
GO:0030054 [cell junction]
GO:0031527 [filopodium membrane]
GO:0032584 [growth cone membrane]
GO:0040008 [regulation of growth]
GO:0051489 [regulation of filopodium assembly]
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 238 aa
24.8 kDa 		No 0
GAP43-002
ENSP00000377372
ENST00000393780
P17677 [Direct mapping]
Neuromodulin
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001786 [phosphatidylserine binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0009611 [response to wounding]
GO:0010001 [glial cell differentiation]
GO:0014069 [postsynaptic density]
GO:0016198 [axon choice point recognition]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0031527 [filopodium membrane]
GO:0032584 [growth cone membrane]
GO:0035727 [lysophosphatidic acid binding]
GO:0040008 [regulation of growth]
GO:0042246 [tissue regeneration]
GO:0045165 [cell fate commitment]
GO:0051489 [regulation of filopodium assembly]
GO:0071944 [cell periphery]
GO:0097481 [neuronal postsynaptic density]
GO:1901981 [phosphatidylinositol phosphate binding]
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 274 aa
28.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.