We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
GAP43
  • premium

    TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

GAP43

Gene description

Growth associated protein 43

Protein class

Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus)
FANTOM5:Group enriched (brain, caudate, cerebellum, hippocampus)

Protein evidence

Evidence at protein level

Protein expression

Selective expression in the CNS and peripheral nerves.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA013392 , HPA015600 , CAB004417
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus)

GENE INFORMATION

Gene name

GAP43 (HGNC Symbol)

Synonyms

B-50, PP46

Description

Growth associated protein 43 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q13.31

Chromosome location (bp)

115623324 - 115721490

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000172020 (version 83.38)

Entrez gene

2596

UniProt

P17677 (UniProt - Evidence at protein level)

neXtProt

NX_P17677

Antibodypedia

GAP43 antibodies

PROTEIN BROWSER

GAP43-001
GAP43-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GAP43-001
ENSP00000305010
ENST00000305124
P17677 [Direct mapping]
Neuromodulin
Q5U058 [Target identity:100%; Query identity:100%]
Growth associated protein 43; cDNA, FLJ94238, Homo sapiens growth associated protein 43 (GAP43), mRNA
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0009611 [response to wounding]
GO:0014069 [postsynaptic density]
GO:0030054 [cell junction]
GO:0031527 [filopodium membrane]
GO:0032584 [growth cone membrane]
GO:0040008 [regulation of growth]
GO:0051489 [regulation of filopodium assembly]
Show all
238 aa
24.8 kDa
No 0
GAP43-002
ENSP00000377372
ENST00000393780
P17677 [Direct mapping]
Neuromodulin
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001786 [phosphatidylserine binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0009611 [response to wounding]
GO:0010001 [glial cell differentiation]
GO:0014069 [postsynaptic density]
GO:0016198 [axon choice point recognition]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0031527 [filopodium membrane]
GO:0032584 [growth cone membrane]
GO:0035727 [lysophosphatidic acid binding]
GO:0040008 [regulation of growth]
GO:0042246 [tissue regeneration]
GO:0045165 [cell fate commitment]
GO:0051489 [regulation of filopodium assembly]
GO:0071944 [cell periphery]
GO:0097481 [neuronal postsynaptic density]
GO:1901981 [phosphatidylinositol phosphate binding]
Show all
274 aa
28.8 kDa
No 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.