Expression of COL6A5 in cancer - Summary - The Human Protein Atlas

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COL6A5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	COL6A5
Gene description	Collagen, type VI, alpha 5
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enriched (HDLM-2)
HPA (normal tissue):	Group enriched (lung, skin)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA043138
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043138

GENE INFORMATION
Gene name	COL6A5 (HGNC Symbol)
Synonyms	COL29A1, FLJ35880, VWA4
Description	Collagen, type VI, alpha 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the collagen superfamily of proteins. The encoded protein contains multiple von Willebrand factor A-like domains and may interact with the alpha 1 and alpha 2 chains of collagen VI to form the complete collagen VI trimer. Polymorphisms in this gene may be linked to dermal phenotypes, such as eczema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Chromosome	3
Cytoband	q22.1
Chromosome location (bp)	130345516 - 130484844
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000172752 (version 83.38)
Entrez gene	256076
UniProt
neXtProt
Antibodypedia	COL6A5 antibodies

PROTEIN BROWSER

COL6A5-002	COL6A5-003	COL6A5-004	COL6A5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COL6A5-002 ENSP00000424968 ENST00000512482	H0Y9T2 [Direct mapping] Collagen alpha-5(VI) chain Show all	Predicted intracellular proteins Show all		443 aa 50.2 kDa	No	0
COL6A5-003 ENSP00000422898 ENST00000512836	H0Y935 [Direct mapping] Collagen alpha-5(VI) chain Show all	Predicted intracellular proteins Show all		778 aa 88.6 kDa	No	0
COL6A5-004 ENSP00000362250 ENST00000373157	H0Y393 [Direct mapping] Collagen alpha-5(VI) chain Show all	Predicted intracellular proteins Show all		557 aa 63.5 kDa	No	0
COL6A5-201 ENSP00000265379 ENST00000265379	E9PAL5 [Direct mapping] Collagen alpha-5(VI) chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005578 [proteinaceous extracellular matrix] Show all	2611 aa 289.5 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.