Tissue expression of COL6A5 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	COL6A5
Gene description	Collagen, type VI, alpha 5
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (lung, skin)
GTEx:	Tissue enhanced (lung, testis)
FANTOM5:	Not detected

Protein evidence

Evidence at transcript level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA043138
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (lung, skin)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung, testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Not detected

GENE INFORMATION
Gene name	COL6A5 (HGNC Symbol)
Synonyms	COL29A1, FLJ35880, VWA4
Description	Collagen, type VI, alpha 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the collagen superfamily of proteins. The encoded protein contains multiple von Willebrand factor A-like domains and may interact with the alpha 1 and alpha 2 chains of collagen VI to form the complete collagen VI trimer. Polymorphisms in this gene may be linked to dermal phenotypes, such as eczema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Chromosome	3
Cytoband	q22.1
Chromosome location (bp)	130345516 - 130484844
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000172752 (version 83.38)
Entrez gene	256076
UniProt
neXtProt
Antibodypedia	COL6A5 antibodies

PROTEIN BROWSER

COL6A5-002	COL6A5-003	COL6A5-004	COL6A5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COL6A5-002 ENSP00000424968 ENST00000512482	H0Y9T2 [Direct mapping] Collagen alpha-5(VI) chain Show all	Predicted intracellular proteins Show all		443 aa 50.2 kDa	No	0
COL6A5-003 ENSP00000422898 ENST00000512836	H0Y935 [Direct mapping] Collagen alpha-5(VI) chain Show all	Predicted intracellular proteins Show all		778 aa 88.6 kDa	No	0
COL6A5-004 ENSP00000362250 ENST00000373157	H0Y393 [Direct mapping] Collagen alpha-5(VI) chain Show all	Predicted intracellular proteins Show all		557 aa 63.5 kDa	No	0
COL6A5-201 ENSP00000265379 ENST00000265379	E9PAL5 [Direct mapping] Collagen alpha-5(VI) chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005578 [proteinaceous extracellular matrix] Show all	2611 aa 289.5 kDa	Yes	0