Cell atlas - KRT2 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KRT2
Gene description	Keratin 2, type II
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & intermediate filaments. In addition localized to the Golgi apparatus.
RNA cell category	Cell line enhanced (HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Intermediate filaments (approved), Cytosol (approved)
Additional location	In addition localized to the Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA006299
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & intermediate filaments. In addition localized to the Golgi apparatus.

Main location

Intermediate filaments (approved), Cytosol (approved)

Additional location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA006299	A-431	Intermediate filaments
HPA006299	A-431	Cytosol
HPA006299	U-2 OS	Intermediate filaments
HPA006299	U-2 OS	Cytosol
HPA006299	U-251 MG	Golgi apparatus
HPA006299	U-251 MG	Cytosol

GENE INFORMATION
Gene name	KRT2 (HGNC Symbol)
Synonyms	KRT2A, KRTE
Description	Keratin 2, type II (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	52644558 - 52652164
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000172867 (version 83.38)
Entrez gene	3849
UniProt	P35908 (UniProt - Evidence at protein level)
neXtProt	NX_P35908
Antibodypedia	KRT2 antibodies

PROTEIN BROWSER

KRT2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT2-001 ENSP00000310861 ENST00000309680	P35908 [Direct mapping] Keratin, type II cytoskeletal 2 epidermal Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005882 [intermediate filament] GO:0008544 [epidermis development] GO:0016020 [membrane] GO:0031424 [keratinization] GO:0032980 [keratinocyte activation] GO:0043616 [keratinocyte proliferation] GO:0045095 [keratin filament] GO:0045111 [intermediate filament cytoskeleton] GO:0051546 [keratinocyte migration] GO:0070062 [extracellular exosome] Show all	639 aa 65.4 kDa	No	0