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KRT2

GENERAL INFORMATION

Gene name

 KRT2

Gene description

 Keratin 2, type II

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (head and neck cancer, melanoma)
HPA (cell line):Cell line enhanced (HEL)
HPA (normal tissue):Tissue enriched (skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in squamous epithelium

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB037321
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (head and neck cancer, melanoma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
CAB037321

GENE INFORMATION

Gene name

 KRT2 (HGNC Symbol)

Synonyms

 KRT2A, KRTE

Description

 Keratin 2, type II (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 52644558 - 52652164

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000172867 (version 83.38)

Entrez gene

 3849

UniProt

 P35908 (UniProt - Evidence at protein level)

neXtProt

 NX_P35908

Antibodypedia

 KRT2 antibodies

PROTEIN BROWSER
KRT2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT2-001
ENSP00000310861
ENST00000309680
P35908 [Direct mapping]
Keratin, type II cytoskeletal 2 epidermal
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005882 [intermediate filament]
GO:0008544 [epidermis development]
GO:0016020 [membrane]
GO:0031424 [keratinization]
GO:0032980 [keratinocyte activation]
GO:0043616 [keratinocyte proliferation]
GO:0045095 [keratin filament]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051546 [keratinocyte migration]
GO:0070062 [extracellular exosome]
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 639 aa
65.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.