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DMRT2

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GENERAL INFORMATION

Gene name

 DMRT2

Gene description

 Doublesex and mab-3 related transcription factor 2

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transcription factors

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (RPMI-8226, RH-30, SK-MEL-30, WM-115)

Protein evidence

 Evidence at transcript level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RPMI-8226, RH-30, SK-MEL-30, WM-115)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 DMRT2

Synonyms

Description

 Doublesex and mab-3 related transcription factor 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. [provided by RefSeq, Apr 2010]

Chromosome

 9

Cytoband

 p24.3

Chromosome location (bp)

 1049858 - 1057552

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000173253 (version 83.38)

Entrez gene

 10655

UniProt

 Q9Y5R5 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9Y5R5

Antibodypedia

 DMRT2 antibodies

PROTEIN BROWSER
DMRT2-001
DMRT2-002
DMRT2-003
DMRT2-004
DMRT2-007
DMRT2-201
DMRT2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DMRT2-001
ENSP00000350865
ENST00000358146
Q9Y5R5 [Direct mapping]
Doublesex- and mab-3-related transcription factor 2
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0003674 [molecular_function]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008150 [biological_process]
GO:0014807 [regulation of somitogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
Show all
 561 aa
61.8 kDa 		No 0
DMRT2-002
ENSP00000397494
ENST00000412350
Q9Y5R5 [Direct mapping]
Doublesex- and mab-3-related transcription factor 2
Q05C20 [Target identity:100%; Query identity:100%]
DMRT2 protein; cDNA FLJ77088, highly similar to Homo sapiens doublesex and mab-3 related transcription factor 2 (DMRT2), transcript variant 1, mRNA
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0003674 [molecular_function]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008150 [biological_process]
GO:0014807 [regulation of somitogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
Show all
 226 aa
24.5 kDa 		No 1
DMRT2-003
ENSP00000259622
ENST00000259622
Q9Y5R5 [Direct mapping]
Doublesex- and mab-3-related transcription factor 2
Q05C20 [Target identity:100%; Query identity:100%]
DMRT2 protein; cDNA FLJ77088, highly similar to Homo sapiens doublesex and mab-3 related transcription factor 2 (DMRT2), transcript variant 1, mRNA
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0003674 [molecular_function]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008150 [biological_process]
GO:0014807 [regulation of somitogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
Show all
 226 aa
24.5 kDa 		No 1
DMRT2-004
ENSP00000371690
ENST00000382255
Q9Y5R5 [Direct mapping]
Doublesex- and mab-3-related transcription factor 2
Q05C20 [Target identity:100%; Query identity:100%]
DMRT2 protein; cDNA FLJ77088, highly similar to Homo sapiens doublesex and mab-3 related transcription factor 2 (DMRT2), transcript variant 1, mRNA
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0003674 [molecular_function]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008150 [biological_process]
GO:0014807 [regulation of somitogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
Show all
 226 aa
24.5 kDa 		No 1
DMRT2-007
ENSP00000489226
ENST00000635183
Q05C20 [Target identity:100%; Query identity:100%]
DMRT2 protein; cDNA FLJ77088, highly similar to Homo sapiens doublesex and mab-3 related transcription factor 2 (DMRT2), transcript variant 1, mRNA
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 226 aa
24.5 kDa 		No 1
DMRT2-201
ENSP00000305785
ENST00000302441
A0A0A0MR18 [Direct mapping]
Doublesex- and mab-3-related transcription factor 2
Show all
Predicted intracellular proteins
Show all
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0014807 [regulation of somitogenesis]
GO:0042803 [protein homodimerization activity]
Show all
 405 aa
45.2 kDa 		No 0
DMRT2-202
ENSP00000371686
ENST00000382251
Q9Y5R5 [Direct mapping]
Doublesex- and mab-3-related transcription factor 2
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000987 [core promoter proximal region sequence-specific DNA binding]
GO:0003674 [molecular_function]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008150 [biological_process]
GO:0014807 [regulation of somitogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048706 [embryonic skeletal system development]
GO:2000287 [positive regulation of myotome development]
Show all
 561 aa
61.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.