Tissue expression of DMRT2 - Summary - The Human Protein Atlas

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DMRT2

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	DMRT2
Gene description	Doublesex and mab-3 related transcription factor 2
Protein class	Predicted intracellular proteins Predicted membrane proteins Transcription factors
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (parathyroid gland)
GTEx:	Group enriched (breast, kidney)
FANTOM5:	Tissue enhanced (kidney)

Protein evidence

Evidence at transcript level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA029297
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (parathyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (breast, kidney)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (kidney)

GENE INFORMATION
Gene name	DMRT2
Synonyms
Description	Doublesex and mab-3 related transcription factor 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. [provided by RefSeq, Apr 2010]
Chromosome	9
Cytoband	p24.3
Chromosome location (bp)	1049858 - 1057552
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000173253 (version 83.38)
Entrez gene	10655
UniProt	Q9Y5R5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y5R5
Antibodypedia	DMRT2 antibodies

PROTEIN BROWSER

DMRT2-001	DMRT2-002	DMRT2-003	DMRT2-004	DMRT2-007	DMRT2-201	DMRT2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DMRT2-001 ENSP00000350865 ENST00000358146	Q9Y5R5 [Direct mapping] Doublesex- and mab-3-related transcription factor 2 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0003674 [molecular_function] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008150 [biological_process] GO:0014807 [regulation of somitogenesis] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	561 aa 61.8 kDa	No	0
DMRT2-002 ENSP00000397494 ENST00000412350	Q9Y5R5 [Direct mapping] Doublesex- and mab-3-related transcription factor 2 Q05C20 [Target identity:100%; Query identity:100%] DMRT2 protein; cDNA FLJ77088, highly similar to Homo sapiens doublesex and mab-3 related transcription factor 2 (DMRT2), transcript variant 1, mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0003674 [molecular_function] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008150 [biological_process] GO:0014807 [regulation of somitogenesis] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	226 aa 24.5 kDa	No	1
DMRT2-003 ENSP00000259622 ENST00000259622	Q9Y5R5 [Direct mapping] Doublesex- and mab-3-related transcription factor 2 Q05C20 [Target identity:100%; Query identity:100%] DMRT2 protein; cDNA FLJ77088, highly similar to Homo sapiens doublesex and mab-3 related transcription factor 2 (DMRT2), transcript variant 1, mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0003674 [molecular_function] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008150 [biological_process] GO:0014807 [regulation of somitogenesis] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	226 aa 24.5 kDa	No	1
DMRT2-004 ENSP00000371690 ENST00000382255	Q9Y5R5 [Direct mapping] Doublesex- and mab-3-related transcription factor 2 Q05C20 [Target identity:100%; Query identity:100%] DMRT2 protein; cDNA FLJ77088, highly similar to Homo sapiens doublesex and mab-3 related transcription factor 2 (DMRT2), transcript variant 1, mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0003674 [molecular_function] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008150 [biological_process] GO:0014807 [regulation of somitogenesis] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	226 aa 24.5 kDa	No	1
DMRT2-007 ENSP00000489226 ENST00000635183	Q05C20 [Target identity:100%; Query identity:100%] DMRT2 protein; cDNA FLJ77088, highly similar to Homo sapiens doublesex and mab-3 related transcription factor 2 (DMRT2), transcript variant 1, mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	226 aa 24.5 kDa	No	1
DMRT2-201 ENSP00000305785 ENST00000302441	A0A0A0MR18 [Direct mapping] Doublesex- and mab-3-related transcription factor 2 Show all	Predicted intracellular proteins Show all	GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0014807 [regulation of somitogenesis] GO:0042803 [protein homodimerization activity] Show all	405 aa 45.2 kDa	No	0
DMRT2-202 ENSP00000371686 ENST00000382251	Q9Y5R5 [Direct mapping] Doublesex- and mab-3-related transcription factor 2 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0003674 [molecular_function] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008150 [biological_process] GO:0014807 [regulation of somitogenesis] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0048706 [embryonic skeletal system development] GO:2000287 [positive regulation of myotome development] Show all	561 aa 61.8 kDa	No	0

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The Human Protein Atlas

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