Expression of DMRT2 in cancer - Summary - The Human Protein Atlas

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DMRT2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DMRT2
Gene description	Doublesex and mab-3 related transcription factor 2
Protein class	Predicted intracellular proteins Predicted membrane proteins Transcription factors
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (renal cancer)
HPA (cell line):	Cell line enhanced (RH-30, RPMI-8226, SK-MEL-30, WM-115)
HPA (normal tissue):	Tissue enriched (parathyroid gland)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA029297
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029297

GENE INFORMATION
Gene name	DMRT2
Synonyms
Description	Doublesex and mab-3 related transcription factor 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. [provided by RefSeq, Apr 2010]
Chromosome	9
Cytoband	p24.3
Chromosome location (bp)	1049858 - 1057552
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000173253 (version 83.38)
Entrez gene	10655
UniProt	Q9Y5R5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y5R5
Antibodypedia	DMRT2 antibodies

PROTEIN BROWSER

DMRT2-001	DMRT2-002	DMRT2-003	DMRT2-004	DMRT2-007	DMRT2-201	DMRT2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DMRT2-001 ENSP00000350865 ENST00000358146	Q9Y5R5 [Direct mapping] Doublesex- and mab-3-related transcription factor 2 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0003674 [molecular_function] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008150 [biological_process] GO:0014807 [regulation of somitogenesis] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	561 aa 61.8 kDa	No	0
DMRT2-002 ENSP00000397494 ENST00000412350	Q9Y5R5 [Direct mapping] Doublesex- and mab-3-related transcription factor 2 Q05C20 [Target identity:100%; Query identity:100%] DMRT2 protein; cDNA FLJ77088, highly similar to Homo sapiens doublesex and mab-3 related transcription factor 2 (DMRT2), transcript variant 1, mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0003674 [molecular_function] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008150 [biological_process] GO:0014807 [regulation of somitogenesis] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	226 aa 24.5 kDa	No	1
DMRT2-003 ENSP00000259622 ENST00000259622	Q9Y5R5 [Direct mapping] Doublesex- and mab-3-related transcription factor 2 Q05C20 [Target identity:100%; Query identity:100%] DMRT2 protein; cDNA FLJ77088, highly similar to Homo sapiens doublesex and mab-3 related transcription factor 2 (DMRT2), transcript variant 1, mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0003674 [molecular_function] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008150 [biological_process] GO:0014807 [regulation of somitogenesis] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	226 aa 24.5 kDa	No	1
DMRT2-004 ENSP00000371690 ENST00000382255	Q9Y5R5 [Direct mapping] Doublesex- and mab-3-related transcription factor 2 Q05C20 [Target identity:100%; Query identity:100%] DMRT2 protein; cDNA FLJ77088, highly similar to Homo sapiens doublesex and mab-3 related transcription factor 2 (DMRT2), transcript variant 1, mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0003674 [molecular_function] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008150 [biological_process] GO:0014807 [regulation of somitogenesis] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	226 aa 24.5 kDa	No	1
DMRT2-007 ENSP00000489226 ENST00000635183	Q05C20 [Target identity:100%; Query identity:100%] DMRT2 protein; cDNA FLJ77088, highly similar to Homo sapiens doublesex and mab-3 related transcription factor 2 (DMRT2), transcript variant 1, mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	226 aa 24.5 kDa	No	1
DMRT2-201 ENSP00000305785 ENST00000302441	A0A0A0MR18 [Direct mapping] Doublesex- and mab-3-related transcription factor 2 Show all	Predicted intracellular proteins Show all	GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0014807 [regulation of somitogenesis] GO:0042803 [protein homodimerization activity] Show all	405 aa 45.2 kDa	No	0
DMRT2-202 ENSP00000371686 ENST00000382251	Q9Y5R5 [Direct mapping] Doublesex- and mab-3-related transcription factor 2 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0003674 [molecular_function] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008150 [biological_process] GO:0014807 [regulation of somitogenesis] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0048706 [embryonic skeletal system development] GO:2000287 [positive regulation of myotome development] Show all	561 aa 61.8 kDa	No	0

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