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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CSPG4
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CSPG4

Gene description

Chondroitin sulfate proteoglycan 4

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous granular cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 3 antibodies.
HPA002951 , HPA042785 , CAB016189
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

CSPG4 (HGNC Symbol)

Synonyms

HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2

Description

Chondroitin sulfate proteoglycan 4 (HGNC Symbol)

Entrez gene summary

A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q24.2

Chromosome location (bp)

75674322 - 75712848

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173546 (version 83.38)

Entrez gene

1464

UniProt

Q6UVK1 (UniProt - Evidence at protein level)

neXtProt

NX_Q6UVK1

Antibodypedia

CSPG4 antibodies

PROTEIN BROWSER

CSPG4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CSPG4-001
ENSP00000312506
ENST00000308508
Q6UVK1 [Direct mapping]
Chondroitin sulfate proteoglycan 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001525 [angiogenesis]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0005975 [carbohydrate metabolic process]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0008283 [cell proliferation]
GO:0008347 [glial cell migration]
GO:0009986 [cell surface]
GO:0016324 [apical plasma membrane]
GO:0016477 [cell migration]
GO:0019901 [protein kinase binding]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030208 [dermatan sulfate biosynthetic process]
GO:0031258 [lamellipodium membrane]
GO:0035556 [intracellular signal transduction]
GO:0042995 [cell projection]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0048771 [tissue remodeling]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0070062 [extracellular exosome]
Show all
2322 aa
250.5 kDa
Yes 1

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