Tissue expression of CHD2 - Summary - The Human Protein Atlas

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CHD2

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TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CHD2
Gene description	Chromodomain helicase DNA binding protein 2
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression at variable levels in most tissue types.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA060744 , HPA060960
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CHD2 (HGNC Symbol)
Synonyms	DKFZp547I1315, DKFZp686E01200, DKFZp781D1727, FLJ38614
Description	Chromodomain helicase DNA binding protein 2 (HGNC Symbol)
Entrez gene summary	The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q26.1
Chromosome location (bp)	92900189 - 93028005
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173575 (version 83.38)
Entrez gene	1106
UniProt	O14647 (UniProt - Evidence at protein level)
neXtProt	NX_O14647
Antibodypedia	CHD2 antibodies

PROTEIN BROWSER

CHD2-001	CHD2-002	CHD2-003	CHD2-004	CHD2-005	CHD2-006	CHD2-007	CHD2-008	CHD2-010	CHD2-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHD2-001 ENSP00000377747 ENST00000394196	O14647 [Direct mapping] Chromodomain-helicase-DNA-binding protein 2 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001046 [core promoter sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0004003 [ATP-dependent DNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0007517 [muscle organ development] GO:0016568 [chromatin modification] GO:0032508 [DNA duplex unwinding] GO:0042393 [histone binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] GO:0060218 [hematopoietic stem cell differentiation] GO:0070062 [extracellular exosome] Show all	1828 aa 211.3 kDa	No	0
CHD2-002 ENSP00000487299 ENST00000629346	A0A0D9SGA6 [Direct mapping] Chromodomain-helicase-DNA-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.5 kDa	No	0
CHD2-003 ENSP00000486629 ENST00000626874	O14647 [Direct mapping] Chromodomain-helicase-DNA-binding protein 2 A0A024RC75 [Target identity:100%; Query identity:100%] Chromodomain helicase DNA binding protein 2, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001046 [core promoter sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0004003 [ATP-dependent DNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007517 [muscle organ development] GO:0016568 [chromatin modification] GO:0032508 [DNA duplex unwinding] GO:0042393 [histone binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	1739 aa 200.6 kDa	No	0
CHD2-004 ENSP00000487577 ENST00000628375	A0A0D9SGK0 [Direct mapping] Chromodomain-helicase-DNA-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001046 [core promoter sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	425 aa 47.9 kDa	No	0
CHD2-005 ENSP00000406581 ENST00000420239	O14647 [Direct mapping] Chromodomain-helicase-DNA-binding protein 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001046 [core promoter sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0004003 [ATP-dependent DNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007517 [muscle organ development] GO:0016568 [chromatin modification] GO:0032508 [DNA duplex unwinding] GO:0042393 [histone binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	501 aa 56.8 kDa	No	0
CHD2-006 ENSP00000486926 ENST00000627622	A0A0D9SFV4 [Direct mapping] Chromodomain-helicase-DNA-binding protein 2 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		45 aa 5.2 kDa	No	0
CHD2-007 ENSP00000485890 ENST00000625990	A0A0D9SEP7 [Direct mapping] Chromodomain-helicase-DNA-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.9 kDa	No	0
CHD2-008 ENSP00000486487 ENST00000626782	B7Z3I4 [Direct mapping] Chromodomain-helicase-DNA-binding protein 2; cDNA FLJ53879, highly similar to Chromodomain-helicase-DNA-binding protein 2 (EC 3.6.1.-) Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001046 [core promoter sequence-specific DNA binding] GO:0004386 [helicase activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0008152 [metabolic process] Show all	514 aa 58.5 kDa	No	0
CHD2-010 ENSP00000486417 ENST00000625243	A0A0D9SFA3 [Direct mapping] Chromodomain-helicase-DNA-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001046 [core promoter sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	121 aa 14.2 kDa	No	0
CHD2-012 ENSP00000486391 ENST00000625463	A0A0D9SF92 [Direct mapping] Chromodomain-helicase-DNA-binding protein 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001046 [core promoter sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	113 aa 12.7 kDa	No	0

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