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PSMD1
  • TISSUE

  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

PSMD1

Gene description

Proteasome 26S subunit, non-ATPase 1

Protein class

FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 3 antibodies.
HPA036736 , HPA036737 , CAB021092
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

PSMD1 (HGNC Symbol)

Synonyms

P112, Rpn2, S1

Description

Proteasome 26S subunit, non-ATPase 1 (HGNC Symbol)

Entrez gene summary

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2010]

Chromosome

2

Cytoband

q37.1

Chromosome location (bp)

231056864 - 231172827

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173692 (version 83.38)

Entrez gene

5707

UniProt

Q99460 (UniProt - Evidence at protein level)

neXtProt

NX_Q99460

Antibodypedia

PSMD1 antibodies

PROTEIN BROWSER

PSMD1-001
PSMD1-003
PSMD1-005
PSMD1-006
PSMD1-009
PSMD1-201
PSMD1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMD1-001
ENSP00000309474
ENST00000308696
Q99460 [Direct mapping]
26S proteasome non-ATPase regulatory subunit 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000502 [proteasome complex]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0004175 [endopeptidase activity]
GO:0005488 [binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005838 [proteasome regulatory particle]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008540 [proteasome regulatory particle, base subcomplex]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0022624 [proteasome accessory complex]
GO:0030234 [enzyme regulator activity]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034515 [proteasome storage granule]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042176 [regulation of protein catabolic process]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070062 [extracellular exosome]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
953 aa
105.8 kDa
No 1
PSMD1-003
ENSP00000386932
ENST00000409643
Q99460 [Direct mapping]
26S proteasome non-ATPase regulatory subunit 1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000502 [proteasome complex]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0004175 [endopeptidase activity]
GO:0005488 [binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005838 [proteasome regulatory particle]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008540 [proteasome regulatory particle, base subcomplex]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0022624 [proteasome accessory complex]
GO:0030234 [enzyme regulator activity]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034515 [proteasome storage granule]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042176 [regulation of protein catabolic process]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070062 [extracellular exosome]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
922 aa
102.3 kDa
No 0
PSMD1-005
ENSP00000406141
ENST00000440838
C9J9M4 [Direct mapping]
26S proteasome non-ATPase regulatory subunit 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
203 aa
23.1 kDa
No 0
PSMD1-006
ENSP00000390967
ENST00000444007
H7BZR6 [Direct mapping]
26S proteasome non-ATPase regulatory subunit 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
164 aa
18.3 kDa
No 0
PSMD1-009
ENSP00000410061
ENST00000447633
H7C378 [Direct mapping]
26S proteasome non-ATPase regulatory subunit 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
Show all
192 aa
20.3 kDa
Yes 0
PSMD1-201
ENSP00000362738
ENST00000373635
Q99460 [Direct mapping]
26S proteasome non-ATPase regulatory subunit 1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000502 [proteasome complex]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0004175 [endopeptidase activity]
GO:0005488 [binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005838 [proteasome regulatory particle]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008540 [proteasome regulatory particle, base subcomplex]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0022624 [proteasome accessory complex]
GO:0030234 [enzyme regulator activity]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034515 [proteasome storage granule]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042176 [regulation of protein catabolic process]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070062 [extracellular exosome]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
922 aa
102.3 kDa
No 0
PSMD1-202
ENSP00000479986
ENST00000619128
A0A087WW66 [Direct mapping]
26S proteasome non-ATPase regulatory subunit 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0005488 [binding]
GO:0030234 [enzyme regulator activity]
GO:0042176 [regulation of protein catabolic process]
GO:0050790 [regulation of catalytic activity]
Show all
953 aa
105.9 kDa
No 1

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