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JUP

GENERAL INFORMATION

Gene name

 JUP

Gene description

 Junction plakoglobin

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HaCaT)
HPA (normal tissue):Group enriched (esophagus, skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in glandular and epithelial cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Supported based on 2 antibodies.
HPA032047 , CAB002139
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA032047
CAB002139

GENE INFORMATION

Gene name

 JUP (HGNC Symbol)

Synonyms

 CTNNG, DP3, DPIII, PDGB, PKGB

Description

 Junction plakoglobin (HGNC Symbol)

Entrez gene summary

 This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 41754604 - 41786931

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000173801 (version 83.38)

Entrez gene

 3728

UniProt

 P14923 (UniProt - Evidence at protein level)

neXtProt

 NX_P14923

Antibodypedia

 JUP antibodies

PROTEIN BROWSER
JUP-001
JUP-002
JUP-003
JUP-004
JUP-005
JUP-006
JUP-007
JUP-008
JUP-009
JUP-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
JUP-001
ENSP00000311113
ENST00000310706
P14923 [Direct mapping]
Junction plakoglobin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0003713 [transcription coactivator activity]
GO:0004871 [signal transducer activity]
GO:0005198 [structural molecule activity]
GO:0005199 [structural constituent of cell wall]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005925 [focal adhesion]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0014704 [intercalated disc]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016342 [catenin complex]
GO:0016477 [cell migration]
GO:0019903 [protein phosphatase binding]
GO:0030057 [desmosome]
GO:0032993 [protein-DNA complex]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0034333 [adherens junction assembly]
GO:0042127 [regulation of cell proliferation]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042659 [regulation of cell fate specification]
GO:0042803 [protein homodimerization activity]
GO:0045216 [cell-cell junction organization]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050839 [cell adhesion molecule binding]
GO:0050982 [detection of mechanical stimulus]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0070062 [extracellular exosome]
GO:0071603 [endothelial cell-cell adhesion]
GO:0071665 [gamma-catenin-TCF7L2 complex]
GO:0071681 [cellular response to indole-3-methanol]
GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication]
GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
Show all
 745 aa
81.7 kDa 		No 0
JUP-002
ENSP00000394146
ENST00000437187
C9JK18 [Direct mapping]
Junction plakoglobin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0004871 [signal transducer activity]
GO:0005198 [structural molecule activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005913 [cell-cell adherens junction]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0016342 [catenin complex]
GO:0034333 [adherens junction assembly]
GO:0042659 [regulation of cell fate specification]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
Show all
 296 aa
32.4 kDa 		No 0
JUP-003
ENSP00000401034
ENST00000424457
C9JTX4 [Direct mapping]
Junction plakoglobin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0004871 [signal transducer activity]
GO:0005198 [structural molecule activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005913 [cell-cell adherens junction]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0016342 [catenin complex]
GO:0034333 [adherens junction assembly]
GO:0042659 [regulation of cell fate specification]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
Show all
 235 aa
25.7 kDa 		No 0
JUP-004
ENSP00000377507
ENST00000393930
P14923 [Direct mapping]
Junction plakoglobin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0003713 [transcription coactivator activity]
GO:0004871 [signal transducer activity]
GO:0005198 [structural molecule activity]
GO:0005199 [structural constituent of cell wall]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005925 [focal adhesion]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0014704 [intercalated disc]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016342 [catenin complex]
GO:0016477 [cell migration]
GO:0019903 [protein phosphatase binding]
GO:0030057 [desmosome]
GO:0032993 [protein-DNA complex]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0034333 [adherens junction assembly]
GO:0042127 [regulation of cell proliferation]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042659 [regulation of cell fate specification]
GO:0042803 [protein homodimerization activity]
GO:0045216 [cell-cell junction organization]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050839 [cell adhesion molecule binding]
GO:0050982 [detection of mechanical stimulus]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0070062 [extracellular exosome]
GO:0071603 [endothelial cell-cell adhesion]
GO:0071665 [gamma-catenin-TCF7L2 complex]
GO:0071681 [cellular response to indole-3-methanol]
GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication]
GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
Show all
 745 aa
81.7 kDa 		No 0
JUP-005
ENSP00000467065
ENST00000465293
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 3 aa
0.4 kDa 		No 0
JUP-006
ENSP00000389886
ENST00000449889
C9JKY1 [Direct mapping]
Junction plakoglobin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0004871 [signal transducer activity]
GO:0005198 [structural molecule activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005913 [cell-cell adherens junction]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0016342 [catenin complex]
GO:0034333 [adherens junction assembly]
GO:0042659 [regulation of cell fate specification]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
Show all
 298 aa
32.6 kDa 		No 0
JUP-007
ENSP00000411449
ENST00000420370
C9J826 [Direct mapping]
Junction plakoglobin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0004871 [signal transducer activity]
GO:0005198 [structural molecule activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005913 [cell-cell adherens junction]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0016342 [catenin complex]
GO:0034333 [adherens junction assembly]
GO:0042659 [regulation of cell fate specification]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
Show all
 277 aa
30.3 kDa 		No 0
JUP-008
ENSP00000377508
ENST00000393931
P14923 [Direct mapping]
Junction plakoglobin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0003713 [transcription coactivator activity]
GO:0004871 [signal transducer activity]
GO:0005198 [structural molecule activity]
GO:0005199 [structural constituent of cell wall]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005882 [intermediate filament]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005916 [fascia adherens]
GO:0005925 [focal adhesion]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007155 [cell adhesion]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0014704 [intercalated disc]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016342 [catenin complex]
GO:0016477 [cell migration]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030018 [Z disc]
GO:0030057 [desmosome]
GO:0032993 [protein-DNA complex]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0034333 [adherens junction assembly]
GO:0042127 [regulation of cell proliferation]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042659 [regulation of cell fate specification]
GO:0042803 [protein homodimerization activity]
GO:0043588 [skin development]
GO:0045216 [cell-cell junction organization]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050839 [cell adhesion molecule binding]
GO:0050982 [detection of mechanical stimulus]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051291 [protein heterooligomerization]
GO:0070062 [extracellular exosome]
GO:0071603 [endothelial cell-cell adhesion]
GO:0071665 [gamma-catenin-TCF7L2 complex]
GO:0071681 [cellular response to indole-3-methanol]
GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication]
GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
Show all
 745 aa
81.7 kDa 		No 0
JUP-009
ENSP00000409948
ENST00000437369
C9JPI2 [Direct mapping]
Junction plakoglobin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0042659 [regulation of cell fate specification]
Show all
 86 aa
9.7 kDa 		No 0
JUP-012
ENSP00000468347
ENST00000591690
K7ERP3 [Direct mapping]
Junction plakoglobin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0042659 [regulation of cell fate specification]
Show all
 104 aa
11.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.