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JUP
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

JUP

Gene description

Junction plakoglobin

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (esophagus, skin)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in glandular and epithelial cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

Supported based on 2 antibodies.
HPA032047 , CAB002139
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
N/A
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

JUP (HGNC Symbol)

Synonyms

CTNNG, DP3, DPIII, PDGB, PKGB

Description

Junction plakoglobin (HGNC Symbol)

Entrez gene summary

This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q21.2

Chromosome location (bp)

41754604 - 41786931

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173801 (version 83.38)

Entrez gene

3728

UniProt

P14923 (UniProt - Evidence at protein level)

neXtProt

NX_P14923

Antibodypedia

JUP antibodies

PROTEIN BROWSER

JUP-001
JUP-002
JUP-003
JUP-004
JUP-005
JUP-006
JUP-007
JUP-008
JUP-009
JUP-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

JUP-001
ENSP00000311113
ENST00000310706
P14923 [Direct mapping]
Junction plakoglobin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0003713 [transcription coactivator activity]
GO:0004871 [signal transducer activity]
GO:0005198 [structural molecule activity]
GO:0005199 [structural constituent of cell wall]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005925 [focal adhesion]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0014704 [intercalated disc]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016342 [catenin complex]
GO:0016477 [cell migration]
GO:0019903 [protein phosphatase binding]
GO:0030057 [desmosome]
GO:0032993 [protein-DNA complex]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0034333 [adherens junction assembly]
GO:0042127 [regulation of cell proliferation]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042659 [regulation of cell fate specification]
GO:0042803 [protein homodimerization activity]
GO:0045216 [cell-cell junction organization]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050839 [cell adhesion molecule binding]
GO:0050982 [detection of mechanical stimulus]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0070062 [extracellular exosome]
GO:0071603 [endothelial cell-cell adhesion]
GO:0071665 [gamma-catenin-TCF7L2 complex]
GO:0071681 [cellular response to indole-3-methanol]
GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication]
GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
Show all
745 aa
81.7 kDa
No 0
JUP-002
ENSP00000394146
ENST00000437187
C9JK18 [Direct mapping]
Junction plakoglobin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0004871 [signal transducer activity]
GO:0005198 [structural molecule activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005913 [cell-cell adherens junction]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0016342 [catenin complex]
GO:0034333 [adherens junction assembly]
GO:0042659 [regulation of cell fate specification]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
Show all
296 aa
32.4 kDa
No 0
JUP-003
ENSP00000401034
ENST00000424457
C9JTX4 [Direct mapping]
Junction plakoglobin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0004871 [signal transducer activity]
GO:0005198 [structural molecule activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005913 [cell-cell adherens junction]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0016342 [catenin complex]
GO:0034333 [adherens junction assembly]
GO:0042659 [regulation of cell fate specification]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
Show all
235 aa
25.7 kDa
No 0
JUP-004
ENSP00000377507
ENST00000393930
P14923 [Direct mapping]
Junction plakoglobin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0003713 [transcription coactivator activity]
GO:0004871 [signal transducer activity]
GO:0005198 [structural molecule activity]
GO:0005199 [structural constituent of cell wall]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005925 [focal adhesion]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0014704 [intercalated disc]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016342 [catenin complex]
GO:0016477 [cell migration]
GO:0019903 [protein phosphatase binding]
GO:0030057 [desmosome]
GO:0032993 [protein-DNA complex]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0034333 [adherens junction assembly]
GO:0042127 [regulation of cell proliferation]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042659 [regulation of cell fate specification]
GO:0042803 [protein homodimerization activity]
GO:0045216 [cell-cell junction organization]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050839 [cell adhesion molecule binding]
GO:0050982 [detection of mechanical stimulus]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0070062 [extracellular exosome]
GO:0071603 [endothelial cell-cell adhesion]
GO:0071665 [gamma-catenin-TCF7L2 complex]
GO:0071681 [cellular response to indole-3-methanol]
GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication]
GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
Show all
745 aa
81.7 kDa
No 0
JUP-005
ENSP00000467065
ENST00000465293
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
3 aa
0.4 kDa
No 0
JUP-006
ENSP00000389886
ENST00000449889
C9JKY1 [Direct mapping]
Junction plakoglobin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0004871 [signal transducer activity]
GO:0005198 [structural molecule activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005913 [cell-cell adherens junction]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0016342 [catenin complex]
GO:0034333 [adherens junction assembly]
GO:0042659 [regulation of cell fate specification]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
Show all
298 aa
32.6 kDa
No 0
JUP-007
ENSP00000411449
ENST00000420370
C9J826 [Direct mapping]
Junction plakoglobin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0004871 [signal transducer activity]
GO:0005198 [structural molecule activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005913 [cell-cell adherens junction]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0016342 [catenin complex]
GO:0034333 [adherens junction assembly]
GO:0042659 [regulation of cell fate specification]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
Show all
277 aa
30.3 kDa
No 0
JUP-008
ENSP00000377508
ENST00000393931
P14923 [Direct mapping]
Junction plakoglobin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0003713 [transcription coactivator activity]
GO:0004871 [signal transducer activity]
GO:0005198 [structural molecule activity]
GO:0005199 [structural constituent of cell wall]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005882 [intermediate filament]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005916 [fascia adherens]
GO:0005925 [focal adhesion]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0007155 [cell adhesion]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0014704 [intercalated disc]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016342 [catenin complex]
GO:0016477 [cell migration]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030018 [Z disc]
GO:0030057 [desmosome]
GO:0032993 [protein-DNA complex]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0034333 [adherens junction assembly]
GO:0042127 [regulation of cell proliferation]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042659 [regulation of cell fate specification]
GO:0042803 [protein homodimerization activity]
GO:0043588 [skin development]
GO:0045216 [cell-cell junction organization]
GO:0045294 [alpha-catenin binding]
GO:0045296 [cadherin binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050839 [cell adhesion molecule binding]
GO:0050982 [detection of mechanical stimulus]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051291 [protein heterooligomerization]
GO:0070062 [extracellular exosome]
GO:0071603 [endothelial cell-cell adhesion]
GO:0071665 [gamma-catenin-TCF7L2 complex]
GO:0071681 [cellular response to indole-3-methanol]
GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication]
GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
Show all
745 aa
81.7 kDa
No 0
JUP-009
ENSP00000409948
ENST00000437369
C9JPI2 [Direct mapping]
Junction plakoglobin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0042659 [regulation of cell fate specification]
Show all
86 aa
9.7 kDa
No 0
JUP-012
ENSP00000468347
ENST00000591690
K7ERP3 [Direct mapping]
Junction plakoglobin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0042659 [regulation of cell fate specification]
Show all
104 aa
11.4 kDa
No 0

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