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RNA tissue category: Group enriched (esophagus, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GENE INFORMATION
Gene name
JUP (HGNC Symbol)
Synonyms
CTNNG, DP3, DPIII, PDGB, PKGB
Description
Junction plakoglobin (HGNC Symbol)
Entrez gene summary
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002159 [desmosome assembly] GO:0003713 [transcription coactivator activity] GO:0004871 [signal transducer activity] GO:0005198 [structural molecule activity] GO:0005199 [structural constituent of cell wall] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005913 [cell-cell adherens junction] GO:0005915 [zonula adherens] GO:0005925 [focal adhesion] GO:0007016 [cytoskeletal anchoring at plasma membrane] GO:0009898 [cytoplasmic side of plasma membrane] GO:0014704 [intercalated disc] GO:0016337 [single organismal cell-cell adhesion] GO:0016342 [catenin complex] GO:0016477 [cell migration] GO:0019903 [protein phosphatase binding] GO:0030057 [desmosome] GO:0032993 [protein-DNA complex] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0034333 [adherens junction assembly] GO:0042127 [regulation of cell proliferation] GO:0042307 [positive regulation of protein import into nucleus] GO:0042659 [regulation of cell fate specification] GO:0042803 [protein homodimerization activity] GO:0045216 [cell-cell junction organization] GO:0045294 [alpha-catenin binding] GO:0045296 [cadherin binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0050839 [cell adhesion molecule binding] GO:0050982 [detection of mechanical stimulus] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0070062 [extracellular exosome] GO:0071603 [endothelial cell-cell adhesion] GO:0071665 [gamma-catenin-TCF7L2 complex] GO:0071681 [cellular response to indole-3-methanol] GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication] GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication] GO:0086091 [regulation of heart rate by cardiac conduction] GO:0090002 [establishment of protein localization to plasma membrane] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly] GO:0003713 [transcription coactivator activity] GO:0004871 [signal transducer activity] GO:0005198 [structural molecule activity] GO:0005199 [structural constituent of cell wall] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005913 [cell-cell adherens junction] GO:0005915 [zonula adherens] GO:0005925 [focal adhesion] GO:0007016 [cytoskeletal anchoring at plasma membrane] GO:0009898 [cytoplasmic side of plasma membrane] GO:0014704 [intercalated disc] GO:0016337 [single organismal cell-cell adhesion] GO:0016342 [catenin complex] GO:0016477 [cell migration] GO:0019903 [protein phosphatase binding] GO:0030057 [desmosome] GO:0032993 [protein-DNA complex] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0034333 [adherens junction assembly] GO:0042127 [regulation of cell proliferation] GO:0042307 [positive regulation of protein import into nucleus] GO:0042659 [regulation of cell fate specification] GO:0042803 [protein homodimerization activity] GO:0045216 [cell-cell junction organization] GO:0045294 [alpha-catenin binding] GO:0045296 [cadherin binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0050839 [cell adhesion molecule binding] GO:0050982 [detection of mechanical stimulus] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0070062 [extracellular exosome] GO:0071603 [endothelial cell-cell adhesion] GO:0071665 [gamma-catenin-TCF7L2 complex] GO:0071681 [cellular response to indole-3-methanol] GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication] GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication] GO:0086091 [regulation of heart rate by cardiac conduction] GO:0090002 [establishment of protein localization to plasma membrane] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly] GO:0003713 [transcription coactivator activity] GO:0004871 [signal transducer activity] GO:0005198 [structural molecule activity] GO:0005199 [structural constituent of cell wall] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005882 [intermediate filament] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005913 [cell-cell adherens junction] GO:0005915 [zonula adherens] GO:0005916 [fascia adherens] GO:0005925 [focal adhesion] GO:0007016 [cytoskeletal anchoring at plasma membrane] GO:0007155 [cell adhesion] GO:0009898 [cytoplasmic side of plasma membrane] GO:0014704 [intercalated disc] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016327 [apicolateral plasma membrane] GO:0016328 [lateral plasma membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0016342 [catenin complex] GO:0016477 [cell migration] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0030018 [Z disc] GO:0030057 [desmosome] GO:0032993 [protein-DNA complex] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0034333 [adherens junction assembly] GO:0042127 [regulation of cell proliferation] GO:0042307 [positive regulation of protein import into nucleus] GO:0042659 [regulation of cell fate specification] GO:0042803 [protein homodimerization activity] GO:0043588 [skin development] GO:0045216 [cell-cell junction organization] GO:0045294 [alpha-catenin binding] GO:0045296 [cadherin binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0050839 [cell adhesion molecule binding] GO:0050982 [detection of mechanical stimulus] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051291 [protein heterooligomerization] GO:0070062 [extracellular exosome] GO:0071603 [endothelial cell-cell adhesion] GO:0071665 [gamma-catenin-TCF7L2 complex] GO:0071681 [cellular response to indole-3-methanol] GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication] GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication] GO:0086091 [regulation of heart rate by cardiac conduction] GO:0090002 [establishment of protein localization to plasma membrane] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0098911 [regulation of ventricular cardiac muscle cell action potential]