Fields »
ABOUT
HELP
BLOG
DDX23

GENERAL INFORMATION

Gene name

 DDX23

Gene description

 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA038680
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038680

GENE INFORMATION

Gene name

 DDX23 (HGNC Symbol)

Synonyms

 prp28, PRPF28, SNRNP100, U5-100K

Description

 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 48829764 - 48852842

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174243 (version 83.38)

Entrez gene

 9416

UniProt

 Q9BUQ8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BUQ8

Antibodypedia

 DDX23 antibodies

PROTEIN BROWSER
DDX23-001
DDX23-004
DDX23-005
DDX23-019

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDX23-001
ENSP00000310723
ENST00000308025
Q9BUQ8 [Direct mapping]
Probable ATP-dependent RNA helicase DDX23
A0A024R0Z3 [Target identity:100%; Query identity:100%]
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000354 [cis assembly of pre-catalytic spliceosome]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005682 [U5 snRNP]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0010501 [RNA secondary structure unwinding]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 820 aa
95.6 kDa 		No 0
DDX23-004
ENSP00000449639
ENST00000552512
F8VVA2 [Direct mapping]
Probable ATP-dependent RNA helicase DDX23
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0010501 [RNA secondary structure unwinding]
Show all
 182 aa
21.8 kDa 		No 0
DDX23-005
ENSP00000446948
ENST00000551468
F8W1J5 [Direct mapping]
Probable ATP-dependent RNA helicase DDX23
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0010501 [RNA secondary structure unwinding]
Show all
 138 aa
16.8 kDa 		No 0
DDX23-019
ENSP00000449657
ENST00000550834
H0YIL9 [Direct mapping]
Probable ATP-dependent RNA helicase DDX23
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0010501 [RNA secondary structure unwinding]
Show all
 259 aa
30.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.