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DDX23

GENERAL INFORMATION

Gene name

 DDX23

Gene description

 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA038680
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DDX23 (HGNC Symbol)

Synonyms

 prp28, PRPF28, SNRNP100, U5-100K

Description

 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 48829764 - 48852842

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174243 (version 83.38)

Entrez gene

 9416

UniProt

 Q9BUQ8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BUQ8

Antibodypedia

 DDX23 antibodies

PROTEIN BROWSER
DDX23-001
DDX23-004
DDX23-005
DDX23-019

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDX23-001
ENSP00000310723
ENST00000308025
Q9BUQ8 [Direct mapping]
Probable ATP-dependent RNA helicase DDX23
A0A024R0Z3 [Target identity:100%; Query identity:100%]
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23, isoform CRA_b
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Enzymes
   ENZYME proteins
   Hydrolases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000354 [cis assembly of pre-catalytic spliceosome]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005682 [U5 snRNP]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0010501 [RNA secondary structure unwinding]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
GO:0071013 [catalytic step 2 spliceosome]
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 820 aa
95.6 kDa 		No 0
DDX23-004
ENSP00000449639
ENST00000552512
F8VVA2 [Direct mapping]
Probable ATP-dependent RNA helicase DDX23
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0010501 [RNA secondary structure unwinding]
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 182 aa
21.8 kDa 		No 0
DDX23-005
ENSP00000446948
ENST00000551468
F8W1J5 [Direct mapping]
Probable ATP-dependent RNA helicase DDX23
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0010501 [RNA secondary structure unwinding]
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 138 aa
16.8 kDa 		No 0
DDX23-019
ENSP00000449657
ENST00000550834
H0YIL9 [Direct mapping]
Probable ATP-dependent RNA helicase DDX23
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0010501 [RNA secondary structure unwinding]
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 259 aa
30.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.