Cell atlas - ZCCHC12 - The Human Protein Atlas

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ZCCHC12

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ZCCHC12
Gene description	Zinc finger, CCHC domain containing 12
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear bodies.
RNA cell category	Cell line enhanced (HEK 293, NTERA-2, SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA031016
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEK 293, NTERA-2, SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear bodies.

Main location

Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA031016	A-431	Nuclear bodies
	HPA031016	HEK 293	Nuclear bodies
	HPA031016	U-2 OS	Nuclear bodies

GENE INFORMATION
Gene name	ZCCHC12 (HGNC Symbol)
Synonyms	FLJ16123, PNMA7A, SIZN, SIZN1
Description	Zinc finger, CCHC domain containing 12 (HGNC Symbol)
Entrez gene summary	This gene encodes a downstream effector of bone morphogenetic protein (BMP) signalling. This protein contains a zinc finger domain and functions as a transcriptional coactivator. Variation in this gene may be associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Chromosome	X
Cytoband	q24
Chromosome location (bp)	118823790 - 118826968
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174460 (version 83.38)
Entrez gene	170261
UniProt	Q6PEW1 (UniProt - Evidence at protein level)
neXtProt	NX_Q6PEW1
Antibodypedia	ZCCHC12 antibodies

PROTEIN BROWSER

ZCCHC12-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZCCHC12-001 ENSP00000308921 ENST00000310164	Q6PEW1 [Direct mapping] Zinc finger CCHC domain-containing protein 12 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016607 [nuclear speck] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030509 [BMP signaling pathway] Show all	402 aa 45.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.