Expression of ZCCHC12 in cancer - Summary

GENERAL INFORMATION
Gene name	ZCCHC12
Gene description	Zinc finger, CCHC domain containing 12
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (thyroid cancer)
HPA (cell line):	Cell line enhanced (HEK93, NTERA-2, SH-SY5Y)
HPA (normal tissue):	Group enriched (endometrium, fallopian tube, smooth muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and nucleolar expression in a subset of tissues including the CNS, fallopian tube and testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 2 antibodies. HPA031016 , HPA034940
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (favourable).
Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (thyroid cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA031016	HPA034940

GENE INFORMATION
Gene name	ZCCHC12 (HGNC Symbol)
Synonyms	FLJ16123, PNMA7A, SIZN, SIZN1
Description	Zinc finger, CCHC domain containing 12 (HGNC Symbol)
Entrez gene summary	This gene encodes a downstream effector of bone morphogenetic protein (BMP) signalling. This protein contains a zinc finger domain and functions as a transcriptional coactivator. Variation in this gene may be associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Chromosome	X
Cytoband	q24
Chromosome location (bp)	118823790 - 118826968
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000174460 (version 83.38)
Entrez gene	170261
UniProt	Q6PEW1 (UniProt - Evidence at protein level)
neXtProt	NX_Q6PEW1
Antibodypedia	ZCCHC12 antibodies

PROTEIN BROWSER

ZCCHC12-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZCCHC12-001 ENSP00000308921 ENST00000310164	Q6PEW1 [Direct mapping] Zinc finger CCHC domain-containing protein 12 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016607 [nuclear speck] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030509 [BMP signaling pathway] Show all	402 aa 45.4 kDa	No	0