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ZCCHC12

GENERAL INFORMATION

Gene name

 ZCCHC12

Gene description

 Zinc finger, CCHC domain containing 12

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (endometrium, fallopian tube, smooth muscle)
GTEx:Tissue enhanced (endometrium, fallopian tube, hypothalamus)
FANTOM5:Tissue enhanced (cerebellum, endometrium)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and nucleolar expression in a subset of tissues including the CNS, fallopian tube and testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 2 antibodies.
HPA031016 , HPA034940
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (endometrium, fallopian tube, smooth muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (endometrium, fallopian tube, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, endometrium)

GENE INFORMATION

Gene name

 ZCCHC12 (HGNC Symbol)

Synonyms

 FLJ16123, PNMA7A, SIZN, SIZN1

Description

 Zinc finger, CCHC domain containing 12 (HGNC Symbol)

Entrez gene summary

 This gene encodes a downstream effector of bone morphogenetic protein (BMP) signalling. This protein contains a zinc finger domain and functions as a transcriptional coactivator. Variation in this gene may be associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Chromosome

 X

Cytoband

 q24

Chromosome location (bp)

 118823790 - 118826968

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000174460 (version 83.38)

Entrez gene

 170261

UniProt

 Q6PEW1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6PEW1

Antibodypedia

 ZCCHC12 antibodies

PROTEIN BROWSER
ZCCHC12-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZCCHC12-001
ENSP00000308921
ENST00000310164
Q6PEW1 [Direct mapping]
Zinc finger CCHC domain-containing protein 12
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Predicted intracellular proteins
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GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0006351 [transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0016607 [nuclear speck]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0030509 [BMP signaling pathway]
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 402 aa
45.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.