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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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A2M
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

A2M

Gene description

Alpha-2-macroglobulin

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Extracellular positivity, mainly in plasma.

DATA RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Reliability score

Supported based on 2 antibodies.
HPA002265 , CAB017621
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

A2M (HGNC Symbol)

Synonyms

CPAMD5, FWP007, S863-7

Description

Alpha-2-macroglobulin (HGNC Symbol)

Entrez gene summary

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

p13.31

Chromosome location (bp)

9067664 - 9116229

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175899 (version 83.38)

Entrez gene

2

UniProt

P01023 (UniProt - Evidence at protein level)

neXtProt

NX_P01023

Antibodypedia

A2M antibodies

PROTEIN BROWSER

A2M-001
A2M-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

A2M-001
ENSP00000323929
ENST00000318602
P01023 [Direct mapping]
Alpha-2-macroglobulin
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001869 [negative regulation of complement activation, lectin pathway]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0004866 [endopeptidase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0007597 [blood coagulation, intrinsic pathway]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0019838 [growth factor binding]
GO:0019899 [enzyme binding]
GO:0019959 [interleukin-8 binding]
GO:0019966 [interleukin-1 binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031093 [platelet alpha granule lumen]
GO:0043120 [tumor necrosis factor binding]
GO:0048306 [calcium-dependent protein binding]
GO:0048863 [stem cell differentiation]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
Show all
1474 aa
163.3 kDa
Yes 0
A2M-002
ENSP00000385710
ENST00000404455
F8W7L3 [Direct mapping]
Alpha-2-macroglobulin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004866 [endopeptidase inhibitor activity]
GO:0010951 [negative regulation of endopeptidase activity]
Show all
168 aa
18.7 kDa
Yes 0

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