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CIDEA

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GENERAL INFORMATION

Gene name

 CIDEA

Gene description

 Cell death-inducing DFFA-like effector a

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CIDEA (HGNC Symbol)

Synonyms

 CIDE-A

Description

 Cell death-inducing DFFA-like effector a (HGNC Symbol)

Entrez gene summary

 This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010]

Chromosome

 18

Cytoband

 p11.21

Chromosome location (bp)

 12254319 - 12277595

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176194 (version 83.38)

Entrez gene

 1149

UniProt

 O60543 (UniProt - Evidence at protein level)

neXtProt

 NX_O60543

Antibodypedia

 CIDEA antibodies

PROTEIN BROWSER
CIDEA-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CIDEA-002
ENSP00000320209
ENST00000320477
O60543 [Direct mapping]
Cell death activator CIDE-A
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0001659 [temperature homeostasis]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005740 [mitochondrial envelope]
GO:0005811 [lipid particle]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006629 [lipid metabolic process]
GO:0006915 [apoptotic process]
GO:0008219 [cell death]
GO:0010890 [positive regulation of sequestering of triglyceride]
GO:0019915 [lipid storage]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0035634 [response to stilbenoid]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0050710 [negative regulation of cytokine secretion]
GO:0050995 [negative regulation of lipid catabolic process]
GO:1900118 [negative regulation of execution phase of apoptosis]
GO:1902510 [regulation of apoptotic DNA fragmentation]
Show all
 219 aa
24.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.