Fields »
ABOUT
HELP
BLOG
CIDEA

GENERAL INFORMATION

Gene name

 CIDEA

Gene description

 Cell death-inducing DFFA-like effector a

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (adipose tissue)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CIDEA (HGNC Symbol)

Synonyms

 CIDE-A

Description

 Cell death-inducing DFFA-like effector a (HGNC Symbol)

Entrez gene summary

 This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010]

Chromosome

 18

Cytoband

 p11.21

Chromosome location (bp)

 12254319 - 12277595

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176194 (version 83.38)

Entrez gene

 1149

UniProt

 O60543 (UniProt - Evidence at protein level)

neXtProt

 NX_O60543

Antibodypedia

 CIDEA antibodies

PROTEIN BROWSER
CIDEA-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CIDEA-002
ENSP00000320209
ENST00000320477
O60543 [Direct mapping]
Cell death activator CIDE-A
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0001659 [temperature homeostasis]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005740 [mitochondrial envelope]
GO:0005811 [lipid particle]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006629 [lipid metabolic process]
GO:0006915 [apoptotic process]
GO:0008219 [cell death]
GO:0010890 [positive regulation of sequestering of triglyceride]
GO:0019915 [lipid storage]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0035634 [response to stilbenoid]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0050710 [negative regulation of cytokine secretion]
GO:0050995 [negative regulation of lipid catabolic process]
GO:1900118 [negative regulation of execution phase of apoptosis]
GO:1902510 [regulation of apoptotic DNA fragmentation]
Show all
 219 aa
24.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.