Tissue expression of CIDEA - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CIDEA
Gene description	Cell death-inducing DFFA-like effector a
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (adipose tissue)
GTEx:	Group enriched (adipose tissue, breast)
FANTOM5:	Tissue enhanced (adipose tissue, breast)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (adipose tissue)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (adipose tissue, breast)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue, breast)

GENE INFORMATION
Gene name	CIDEA (HGNC Symbol)
Synonyms	CIDE-A
Description	Cell death-inducing DFFA-like effector a (HGNC Symbol)
Entrez gene summary	This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010]
Chromosome	18
Cytoband	p11.21
Chromosome location (bp)	12254319 - 12277595
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176194 (version 83.38)
Entrez gene	1149
UniProt	O60543 (UniProt - Evidence at protein level)
neXtProt	NX_O60543
Antibodypedia	CIDEA antibodies

PROTEIN BROWSER

CIDEA-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CIDEA-002 ENSP00000320209 ENST00000320477	O60543 [Direct mapping] Cell death activator CIDE-A Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0001659 [temperature homeostasis] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005811 [lipid particle] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006629 [lipid metabolic process] GO:0006915 [apoptotic process] GO:0008219 [cell death] GO:0010890 [positive regulation of sequestering of triglyceride] GO:0019915 [lipid storage] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0035634 [response to stilbenoid] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0050710 [negative regulation of cytokine secretion] GO:0050995 [negative regulation of lipid catabolic process] GO:1900118 [negative regulation of execution phase of apoptosis] GO:1902510 [regulation of apoptotic DNA fragmentation] Show all	219 aa 24.7 kDa	No	0