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SOX11

ANTIBODY INFORMATION
 
 

Antibody HPA000536

  

Antibody CAB056152

  

Antibody CAB056153

  

Provider

 Atlas Antibodies
Sigma-Aldrich
   Atlas Antibodies
Sigma-Aldrich
   Atlas Antibodies
Sigma-Aldrich
  

Product name

 HPA000536   AMAb90501   AMAb90502  

Host species

 Rabbit   Mouse   Mouse  

Clonality

 pAb   mAb   mAb  

Purity

 Affinity purified using the PrEST-antigen as affinity ligand   Protein A/G   Protein A/G  

Other gene match

      

Released in version

 2   10   14  

References

 19      

Proper citation

 Atlas Antibodies Cat#HPA000536, RRID:AB_1080060   Atlas Antibodies Cat#AMAb90501, RRID:AB_2665567   Atlas Antibodies Cat#AMAb90502, RRID:AB_2665568  

VALIDATION SUMMARY
 
 

Antibody HPA000536

  

Antibody CAB056152

  

Antibody CAB056153

  
Immunohistochemistry

Approved   Approved   Approved  
Western blot

Uncertain   Uncertain   Uncertain  
Protein array

Supported      

IMMUNOHISTOCHEMISTRY
 
 

Antibody HPA000536

  

Antibody CAB056152

  

Antibody CAB056153

  

Standard validation

 Approved   Approved   Approved  

     

Figure description

 Immunohistochemical staining of human lateral ventricle shows nuclear positivity in glial cells.   Immunohistochemical staining of human small intestine shows moderate nuclear positivity in subsets of cells.   Immunohistochemical staining of human colon shows nuclear positivity in subsets of glandular cells.  

Expression

 RNA: detected in 1 tissues
Protein: detected in 33 cell types		   RNA: detected in 1 tissues
Protein: detected in 9 cell types		   RNA: detected in 1 tissues
Protein: detected in 12 cell types		  

Retrieval

 HIER pH6   HIER pH6   HIER pH6  

Antibody dilution

 1:100   1:500   1:500  

Literature conformity

 Partly consistent with extensive gene/protein characterization data.   Partly consistent with extensive gene/protein characterization data.   Partly consistent with extensive gene/protein characterization data.  

RNA consistency

 Mainly not consistent with RNA expression data.   Not consistent with RNA expression data.   Mainly not consistent with RNA expression data.  

WESTERN BLOT
 
 

Antibody HPA000536

  

Antibody CAB056152

  

Antibody CAB056153

  

Standard validation

 Uncertain

Analysis performed using a standard panel of samples.
Current setup is not applicable due to low RNA count.		   Uncertain

Analysis performed using a standard panel of samples.
Current setup is not applicable due to low RNA count.		   Uncertain

Analysis performed using a standard panel of samples.
Current setup is not applicable due to low RNA count.		  

     

Figure description

      

Target mass (kDa)

 46.7   46.7   46.7  

Antibody dilution

 1:500   1:1000   1:500  

PROTEIN ARRAY
 
 

Antibody HPA000536

  

Antibody CAB056152

  

Antibody CAB056153

  

Standard validation

 Supported

Pass with single peak corresponding to interaction only with its own antigen.		      

     

Figure description

 Antibody specificity analysis with protein arrays. Predicted and matching interactions are shown in green.      

Antibody dilution

 1:2000      

ANTIGEN INFORMATION
 
 

Antibody HPA000536

  

Antibody CAB056152

  

Antibody CAB056153

  

Antigen

 Recombinant protein fragment   Recombinant protein   Recombinant protein  

Length (aa)

 111      

Antigen sequence

 
FMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERL
RLKHMADYPDYKYRPRKKPKMDPSAKPSASQSPEKSAAGGGGGSAGGGAG
GAKTSKGSSKK
     

Matching transcripts

 SOX11-001 - ENSP00000322568 [100%]
     

Other gene match

      
ANTIGEN VIEW
SOX11-001

RELEVANT PUBLICATIONS
 
 

Antibody HPA000536

  

Antibody CAB056152

  

Antibody CAB056153

  

1.

 Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma
Ek S et al
Blood 2008;111(2):800-5
      

2.

 Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms
Chen YH et al
Mod Pathol 2010;23(1):105-12
      

3.

 SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype
Mozos A et al
Haematologica 2009;94(11):1555-62
      

4.

 Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma
Dictor M et al
Haematologica 2009;94(11):1563-8
      

5.

 Genomic and gene expression profiling defines indolent forms of mantle cell lymphoma
Fernàndez V et al
Cancer Res 2010;70(4):1408-18
      

6.

 Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network
Aiden AP et al
Cell Stem Cell 2010;6(6):591-602
      

7.

 SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies
Gustavsson E et al
Mol Cancer 2010;9:187
      

8.

 Gene expression profiling and chromatin immunoprecipitation identify DBN1, SETMAR and HIG2 as direct targets of SOX11 in mantle cell lymphoma
Wang X et al
PLoS One 2010;5(11):e14085
      

9.

 From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies
Ek S et al
Mol Cell Proteomics 2006;5(6):1072-81
      

10.

 In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior
Carvajal-Cuenca A et al
Haematologica 2012;97(2):270-8
      

11.

 The expression of SOX11, cyclin D1, cyclin D2, and cyclin D3 in B-cell lymphocytic proliferative diseases
Cao X et al
Med Oncol 2012;29(2):1190-6
      

12.

 Indolent mantle cell leukemia: a clinicopathological variant characterized by isolated lymphocytosis, interstitial bone marrow involvement, kappa light chain restriction, and good prognosis
Ondrejka SL et al
Haematologica 2011;96(8):1121-7
      

13.

 The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival
Wang X et al
Br J Haematol 2008;143(2):248-52
      

14.

 Prognostic role of SOX11 in a population-based cohort of mantle cell lymphoma
Nygren L et al
Blood 2012;119(18):4215-23
      

15.

 Small cell variant of mantle cell lymphoma is an indolent lymphoma characterized by bone marrow involvement, splenomegaly, and a low Ki-67 index
Kimura Y et al
Cancer Sci 2011;102(9):1734-41
      

16.

 The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation
Sernbo S et al
BMC Cancer 2011;11:405
      

17.

 The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions
Davidson B et al
Hum Pathol 2015;46(1):1-8
Application: IHC 		     

18.

 High-resolution chromatin immunoprecipitation (ChIP) sequencing reveals novel binding targets and prognostic role for SOX11 in mantle cell lymphoma
Kuo PY et al
Oncogene 2015;34(10):1231-40
Application: ChIP, IHC, WB 		     

19.

 Plasma cell and terminal B-cell differentiation in mantle cell lymphoma mainly occur in the SOX11-negative subtype
Ribera-Cortada I et al
Mod Pathol 2015;28(11):1435-47
Application: IHC 		     
 

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The Human Protein Atlas

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