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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SOX11
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SOX11

Gene description

SRY (sex determining region Y)-box 11

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Group enriched (breast cancer, glioma, ovarian cancer, testis cancer)
HPA (cell line):Group enriched (AF22, NTERA-2, REH, RH-30, SCLC-21H, SH-SY5Y, WM-115)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear staining in rare cells in intestine, respiratory eptithelia and breast.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 3 antibodies.
HPA000536 , CAB056152 , CAB056153
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Group enriched (breast cancer, glioma, ovarian cancer, testis cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY

HPA000536
CAB056152
CAB056153

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong nuclear staining was displayed mainly in malignant gliomas, breast and skin cancers. Colorectal cancers showed cytoplasmic positivity. Remaining malignanices were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Two cases of non-hodgkin lymphomas displayed moderate nuclear staining. Cancer cells in general were negative. Several malignant melanomas showed cytoplasmic positivity. A few cases of other cancers displayed weak to moderate cytoplasmic or nuclear staining.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancers were negative. Endometrial cancers and gliomas displayed a differential nuclear staining pattern. Two cases of lymphomas displayed moderate nuclear positivity in a majority of cells.

GENE INFORMATION

Gene name

SOX11

Synonyms

Description

SRY (sex determining region Y)-box 11 (HGNC Symbol)

Entrez gene summary

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p25.2

Chromosome location (bp)

5692667 - 5701385

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000176887 (version 83.38)

Entrez gene

6664

UniProt

P35716 (UniProt - Evidence at protein level)

neXtProt

NX_P35716

Antibodypedia

SOX11 antibodies

PROTEIN BROWSER

SOX11-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOX11-001
ENSP00000322568
ENST00000322002
P35716 [Direct mapping]
Transcription factor SOX-11
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Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001501 [skeletal system development]
GO:0001822 [kidney development]
GO:0001841 [neural tube formation]
GO:0002089 [lens morphogenesis in camera-type eye]
GO:0003151 [outflow tract morphogenesis]
GO:0003211 [cardiac ventricle formation]
GO:0003357 [noradrenergic neuron differentiation]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006412 [translation]
GO:0008135 [translation factor activity, RNA binding]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0014003 [oligodendrocyte development]
GO:0014009 [glial cell proliferation]
GO:0014032 [neural crest cell development]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0021510 [spinal cord development]
GO:0021782 [glial cell development]
GO:0030182 [neuron differentiation]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035332 [positive regulation of hippo signaling]
GO:0035914 [skeletal muscle cell differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045778 [positive regulation of ossification]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046887 [positive regulation of hormone secretion]
GO:0048485 [sympathetic nervous system development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0050672 [negative regulation of lymphocyte proliferation]
GO:0050769 [positive regulation of neurogenesis]
GO:0060022 [hard palate development]
GO:0060023 [soft palate development]
GO:0060174 [limb bud formation]
GO:0060253 [negative regulation of glial cell proliferation]
GO:0060412 [ventricular septum morphogenesis]
GO:0060425 [lung morphogenesis]
GO:0060548 [negative regulation of cell death]
GO:0060563 [neuroepithelial cell differentiation]
GO:0061029 [eyelid development in camera-type eye]
GO:0061053 [somite development]
GO:0061303 [cornea development in camera-type eye]
GO:0061386 [closure of optic fissure]
GO:0072395 [signal transduction involved in cell cycle checkpoint]
GO:2000648 [positive regulation of stem cell proliferation]
GO:2000678 [negative regulation of transcription regulatory region DNA binding]
GO:2001111 [positive regulation of lens epithelial cell proliferation]
Show all
441 aa
46.7 kDa
No 0

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