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Gene name

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Chromosome

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In atlas

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Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

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Expression

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Specificity

Cell line

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Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

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Antibodies

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SOX11
  • TISSUE

  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

SOX11

Gene description

SRY (sex determining region Y)-box 11

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (caudate, hypothalamus)
FANTOM5:Tissue enhanced (caudate, hippocampus)

Protein evidence

Evidence at protein level

Protein expression

Nuclear staining in rare cells in intestine, respiratory eptithelia and breast.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 3 antibodies.
HPA000536 , CAB056152 , CAB056153
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
N/A
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, hippocampus)

GENE INFORMATION

Gene name

SOX11

Synonyms

Description

SRY (sex determining region Y)-box 11 (HGNC Symbol)

Entrez gene summary

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p25.2

Chromosome location (bp)

5692667 - 5701385

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000176887 (version 83.38)

Entrez gene

6664

UniProt

P35716 (UniProt - Evidence at protein level)

neXtProt

NX_P35716

Antibodypedia

SOX11 antibodies

PROTEIN BROWSER

SOX11-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOX11-001
ENSP00000322568
ENST00000322002
P35716 [Direct mapping]
Transcription factor SOX-11
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001501 [skeletal system development]
GO:0001822 [kidney development]
GO:0001841 [neural tube formation]
GO:0002089 [lens morphogenesis in camera-type eye]
GO:0003151 [outflow tract morphogenesis]
GO:0003211 [cardiac ventricle formation]
GO:0003357 [noradrenergic neuron differentiation]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006412 [translation]
GO:0008135 [translation factor activity, RNA binding]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0014003 [oligodendrocyte development]
GO:0014009 [glial cell proliferation]
GO:0014032 [neural crest cell development]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0021510 [spinal cord development]
GO:0021782 [glial cell development]
GO:0030182 [neuron differentiation]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035332 [positive regulation of hippo signaling]
GO:0035914 [skeletal muscle cell differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045778 [positive regulation of ossification]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046887 [positive regulation of hormone secretion]
GO:0048485 [sympathetic nervous system development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0050672 [negative regulation of lymphocyte proliferation]
GO:0050769 [positive regulation of neurogenesis]
GO:0060022 [hard palate development]
GO:0060023 [soft palate development]
GO:0060174 [limb bud formation]
GO:0060253 [negative regulation of glial cell proliferation]
GO:0060412 [ventricular septum morphogenesis]
GO:0060425 [lung morphogenesis]
GO:0060548 [negative regulation of cell death]
GO:0060563 [neuroepithelial cell differentiation]
GO:0061029 [eyelid development in camera-type eye]
GO:0061053 [somite development]
GO:0061303 [cornea development in camera-type eye]
GO:0061386 [closure of optic fissure]
GO:0072395 [signal transduction involved in cell cycle checkpoint]
GO:2000648 [positive regulation of stem cell proliferation]
GO:2000678 [negative regulation of transcription regulatory region DNA binding]
GO:2001111 [positive regulation of lens epithelial cell proliferation]
Show all
441 aa
46.7 kDa
No 0

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