Cell atlas - ACER2 - The Human Protein Atlas

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ACER2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	ACER2
Gene description	Alkaline ceramidase 2
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (RT4, BEWO)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (RT4, BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	ACER2 (HGNC Symbol)
Synonyms	ASAH3L, FLJ41587
Description	Alkaline ceramidase 2 (HGNC Symbol)
Entrez gene summary	The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010]
Chromosome	9
Cytoband	p22.1
Chromosome location (bp)	19409059 - 19452020
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177076 (version 83.38)
Entrez gene	340485
UniProt	Q5QJU3 (UniProt - Evidence at protein level)
neXtProt	NX_Q5QJU3
Antibodypedia	ACER2 antibodies

PROTEIN BROWSER

ACER2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACER2-001 ENSP00000342609 ENST00000340967	Q5QJU3 [Direct mapping] Alkaline ceramidase 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0001953 [negative regulation of cell-matrix adhesion] GO:0005794 [Golgi apparatus] GO:0006665 [sphingolipid metabolic process] GO:0006672 [ceramide metabolic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008284 [positive regulation of cell proliferation] GO:0010942 [positive regulation of cell death] GO:0016021 [integral component of membrane] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0017040 [ceramidase activity] GO:0030148 [sphingolipid biosynthetic process] GO:0030173 [integral component of Golgi membrane] GO:0032526 [response to retinoic acid] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0035690 [cellular response to drug] GO:0044281 [small molecule metabolic process] GO:0046512 [sphingosine biosynthetic process] GO:0071633 [dihydroceramidase activity] GO:0090285 [negative regulation of protein glycosylation in Golgi] Show all	275 aa 31.3 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.