Tissue expression of ACER2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ACER2
Gene description	Alkaline ceramidase 2
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (placenta, stomach, urinary bladder)
GTEx:	Tissue enriched (urinary bladder)
FANTOM5:	Tissue enhanced (vagina)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (placenta, stomach, urinary bladder)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (urinary bladder)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (vagina)

GENE INFORMATION
Gene name	ACER2 (HGNC Symbol)
Synonyms	ASAH3L, FLJ41587
Description	Alkaline ceramidase 2 (HGNC Symbol)
Entrez gene summary	The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010]
Chromosome	9
Cytoband	p22.1
Chromosome location (bp)	19409059 - 19452020
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177076 (version 83.38)
Entrez gene	340485
UniProt	Q5QJU3 (UniProt - Evidence at protein level)
neXtProt	NX_Q5QJU3
Antibodypedia	ACER2 antibodies

PROTEIN BROWSER

ACER2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACER2-001 ENSP00000342609 ENST00000340967	Q5QJU3 [Direct mapping] Alkaline ceramidase 2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0001953 [negative regulation of cell-matrix adhesion] GO:0005794 [Golgi apparatus] GO:0006665 [sphingolipid metabolic process] GO:0006672 [ceramide metabolic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008284 [positive regulation of cell proliferation] GO:0010942 [positive regulation of cell death] GO:0016021 [integral component of membrane] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0017040 [ceramidase activity] GO:0030148 [sphingolipid biosynthetic process] GO:0030173 [integral component of Golgi membrane] GO:0032526 [response to retinoic acid] GO:0033629 [negative regulation of cell adhesion mediated by integrin] GO:0035690 [cellular response to drug] GO:0044281 [small molecule metabolic process] GO:0046512 [sphingosine biosynthetic process] GO:0071633 [dihydroceramidase activity] GO:0090285 [negative regulation of protein glycosylation in Golgi] Show all	275 aa 31.3 kDa	No	7