Fields »
ABOUT
HELP
BLOG
ACER2

GENERAL INFORMATION

Gene name

 ACER2

Gene description

 Alkaline ceramidase 2

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (urothelial cancer)
HPA (cell line):Group enriched (BEWO, RT4)
HPA (normal tissue):Group enriched (placenta, stomach, urinary bladder)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (urothelial cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 ACER2 (HGNC Symbol)

Synonyms

 ASAH3L, FLJ41587

Description

 Alkaline ceramidase 2 (HGNC Symbol)

Entrez gene summary

 The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010]

Chromosome

 9

Cytoband

 p22.1

Chromosome location (bp)

 19409059 - 19452020

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177076 (version 83.38)

Entrez gene

 340485

UniProt

 Q5QJU3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5QJU3

Antibodypedia

 ACER2 antibodies

PROTEIN BROWSER
ACER2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACER2-001
ENSP00000342609
ENST00000340967
Q5QJU3 [Direct mapping]
Alkaline ceramidase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0000139 [Golgi membrane]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0005794 [Golgi apparatus]
GO:0006665 [sphingolipid metabolic process]
GO:0006672 [ceramide metabolic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0010942 [positive regulation of cell death]
GO:0016021 [integral component of membrane]
GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides]
GO:0017040 [ceramidase activity]
GO:0030148 [sphingolipid biosynthetic process]
GO:0030173 [integral component of Golgi membrane]
GO:0032526 [response to retinoic acid]
GO:0033629 [negative regulation of cell adhesion mediated by integrin]
GO:0035690 [cellular response to drug]
GO:0044281 [small molecule metabolic process]
GO:0046512 [sphingosine biosynthetic process]
GO:0071633 [dihydroceramidase activity]
GO:0090285 [negative regulation of protein glycosylation in Golgi]
Show all
 275 aa
31.3 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.