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AURKB

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GENERAL INFORMATION

Gene name

 AURKB

Gene description

 Aurora kinase B

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the midbody & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Midbody (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by biological definition and custom assay

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA037708
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ASSAYS
RNA expression
Human cells
Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the midbody & nucleoplasm.

Main location

 Nucleoplasm (supported), Midbody (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA037708 A-431 Nucleoplasm
HPA037708 HEK 293 Nucleoplasm
HPA037708 U-2 OS Nucleoplasm Intensity Intensity
Midbody Intensity Intensity

CUSTOM DATA

 

 

 
Toggle channels

Thumbnail

Antibody

Cell line

Assay

Description
HPA037708 U-2 OS Image Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. AURKB is mostly expressed at the G1/S checkpoint, and during S and/or G2.
 

Thumbnail

Antibody

Cell line

Assay

Description
HPA037708: U-2 OS
HPA037708 U-2 OS Movie AURKB is a key regulator for the onset of cytokinesis during mitosis, when it is localised to the midbody. Knock down of this gene increases the population doubling time significantly. Furthermore, the cells develop poly-lobed nuclei after division and go into arrest at G1 phase.

CELL CYCLE

Summary

 Expression has cell cycle dependency according to biological definition and custom assay

Intensity variation

 Midbody, Nucleoplasm

GENE INFORMATION

Gene name

 AURKB (HGNC Symbol)

Synonyms

 Aik2, AIM-1, ARK2, AurB, IPL1, PPP1R48, STK12, STK5

Description

 Aurora kinase B (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 8204733 - 8210600

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178999 (version 83.38)

Entrez gene

 9212

UniProt

 Q96GD4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96GD4

Antibodypedia

 AURKB antibodies

PROTEIN BROWSER
AURKB-001
AURKB-002
AURKB-003
AURKB-005
AURKB-008
AURKB-009
AURKB-011
AURKB-012
AURKB-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AURKB-001
ENSP00000463999
ENST00000585124
Q96GD4 [Direct mapping]
Aurora kinase B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0002903 [negative regulation of B cell apoptotic process]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0009838 [abscission]
GO:0016570 [histone modification]
GO:0030496 [midbody]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031577 [spindle checkpoint]
GO:0031616 [spindle pole centrosome]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032466 [negative regulation of cytokinesis]
GO:0032467 [positive regulation of cytokinesis]
GO:0034501 [protein localization to kinetochore]
GO:0034644 [cellular response to UV]
GO:0035174 [histone serine kinase activity]
GO:0036089 [cleavage furrow formation]
GO:0043146 [spindle stabilization]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0051233 [spindle midzone]
GO:0051256 [mitotic spindle midzone assembly]
GO:0051983 [regulation of chromosome segregation]
Show all
 344 aa
39.3 kDa 		No 0
AURKB-002
ENSP00000313950
ENST00000316199
Q96GD4 [Direct mapping]
Aurora kinase B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0002903 [negative regulation of B cell apoptotic process]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007568 [aging]
GO:0008283 [cell proliferation]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0009838 [abscission]
GO:0010369 [chromocenter]
GO:0016570 [histone modification]
GO:0030496 [midbody]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031577 [spindle checkpoint]
GO:0031616 [spindle pole centrosome]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032466 [negative regulation of cytokinesis]
GO:0032467 [positive regulation of cytokinesis]
GO:0034501 [protein localization to kinetochore]
GO:0034644 [cellular response to UV]
GO:0035174 [histone serine kinase activity]
GO:0036089 [cleavage furrow formation]
GO:0043146 [spindle stabilization]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0051233 [spindle midzone]
GO:0051256 [mitotic spindle midzone assembly]
GO:0051983 [regulation of chromosome segregation]
Show all
 345 aa
39.5 kDa 		No 0
AURKB-003
ENSP00000443869
ENST00000534871
Q96GD4 [Direct mapping]
Aurora kinase B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0002903 [negative regulation of B cell apoptotic process]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0009838 [abscission]
GO:0016570 [histone modification]
GO:0030496 [midbody]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031577 [spindle checkpoint]
GO:0031616 [spindle pole centrosome]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032466 [negative regulation of cytokinesis]
GO:0032467 [positive regulation of cytokinesis]
GO:0034501 [protein localization to kinetochore]
GO:0034644 [cellular response to UV]
GO:0035174 [histone serine kinase activity]
GO:0036089 [cleavage furrow formation]
GO:0043146 [spindle stabilization]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0051233 [spindle midzone]
GO:0051256 [mitotic spindle midzone assembly]
GO:0051983 [regulation of chromosome segregation]
Show all
 303 aa
34.8 kDa 		No 0
AURKB-005
ENSP00000462207
ENST00000578549
Q96GD4 [Direct mapping]
Aurora kinase B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000779 [condensed chromosome, centromeric region]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0002903 [negative regulation of B cell apoptotic process]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008608 [attachment of spindle microtubules to kinetochore]
GO:0009838 [abscission]
GO:0016570 [histone modification]
GO:0030496 [midbody]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031577 [spindle checkpoint]
GO:0031616 [spindle pole centrosome]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032466 [negative regulation of cytokinesis]
GO:0032467 [positive regulation of cytokinesis]
GO:0034501 [protein localization to kinetochore]
GO:0034644 [cellular response to UV]
GO:0035174 [histone serine kinase activity]
GO:0036089 [cleavage furrow formation]
GO:0043146 [spindle stabilization]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0051233 [spindle midzone]
GO:0051256 [mitotic spindle midzone assembly]
GO:0051983 [regulation of chromosome segregation]
Show all
 312 aa
35.3 kDa 		No 0
AURKB-008
ENSP00000462930
ENST00000581511
J3KTD6 [Direct mapping]
Aurora kinase B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0031577 [spindle checkpoint]
GO:0031616 [spindle pole centrosome]
GO:0032133 [chromosome passenger complex]
GO:0032467 [positive regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0051233 [spindle midzone]
Show all
 228 aa
26.2 kDa 		No 0
AURKB-009
ENSP00000462027
ENST00000583915
J3KRJ2 [Direct mapping]
Aurora kinase B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0031616 [spindle pole centrosome]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0051233 [spindle midzone]
Show all
 70 aa
7.8 kDa 		No 0
AURKB-011
ENSP00000464031
ENST00000582368
J3QR41 [Direct mapping]
Aurora kinase B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0031577 [spindle checkpoint]
GO:0031616 [spindle pole centrosome]
GO:0032133 [chromosome passenger complex]
GO:0032467 [positive regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0051233 [spindle midzone]
Show all
 172 aa
20 kDa 		No 0
AURKB-012
ENSP00000463636
ENST00000577833
J3QLN8 [Direct mapping]
Aurora kinase B
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0031577 [spindle checkpoint]
GO:0031616 [spindle pole centrosome]
GO:0032133 [chromosome passenger complex]
GO:0032467 [positive regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0051233 [spindle midzone]
Show all
 231 aa
26.8 kDa 		No 0
AURKB-016
ENSP00000462858
ENST00000584972
J3KT86 [Direct mapping]
Aurora kinase B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005876 [spindle microtubule]
GO:0006468 [protein phosphorylation]
GO:0007052 [mitotic spindle organization]
GO:0007067 [mitotic nuclear division]
GO:0031577 [spindle checkpoint]
GO:0031616 [spindle pole centrosome]
GO:0032133 [chromosome passenger complex]
GO:0032467 [positive regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0043988 [histone H3-S28 phosphorylation]
GO:0051233 [spindle midzone]
Show all
 242 aa
28 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.