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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SOX2
  • TISSUE

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  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SOX2

Gene description

SRY (sex determining region Y)-box 2

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enhanced (glioma)
HPA (cell line):Group enriched (AF22, NTERA-2)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in selected tissues, including CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Cytoplasmic staining observed and disregarded.

Reliability score

Approved based on 1 antibody.
CAB010648
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY

CAB010648

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Gliomas and several squamous cell carcinomas showed moderate to strong nuclear staining. Weak cytoplasmic or nuclear in a few other cases. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

SOX2

Synonyms

Description

SRY (sex determining region Y)-box 2 (HGNC Symbol)

Entrez gene summary

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q26.33

Chromosome location (bp)

181711924 - 181714436

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000181449 (version 83.38)

Entrez gene

6657

UniProt

P48431 (UniProt - Evidence at protein level)

neXtProt

NX_P48431

Antibodypedia

SOX2 antibodies

PROTEIN BROWSER

SOX2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOX2-001
ENSP00000323588
ENST00000325404
P48431 [Direct mapping]
Transcription factor SOX-2
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Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001649 [osteoblast differentiation]
GO:0001654 [eye development]
GO:0001708 [cell fate specification]
GO:0001714 [endodermal cell fate specification]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007050 [cell cycle arrest]
GO:0007605 [sensory perception of sound]
GO:0009611 [response to wounding]
GO:0010033 [response to organic substance]
GO:0010468 [regulation of gene expression]
GO:0019827 [stem cell population maintenance]
GO:0021781 [glial cell fate commitment]
GO:0021879 [forebrain neuron differentiation]
GO:0021983 [pituitary gland development]
GO:0021984 [adenohypophysis development]
GO:0021987 [cerebral cortex development]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030539 [male genitalia development]
GO:0030858 [positive regulation of epithelial cell differentiation]
GO:0030900 [forebrain development]
GO:0030910 [olfactory placode formation]
GO:0031490 [chromatin DNA binding]
GO:0032526 [response to retinoic acid]
GO:0035019 [somatic stem cell population maintenance]
GO:0035198 [miRNA binding]
GO:0042246 [tissue regeneration]
GO:0042472 [inner ear morphogenesis]
GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043565 [sequence-specific DNA binding]
GO:0043586 [tongue development]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044798 [nuclear transcription factor complex]
GO:0045165 [cell fate commitment]
GO:0045596 [negative regulation of cell differentiation]
GO:0045597 [positive regulation of cell differentiation]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046148 [pigment biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0048286 [lung alveolus development]
GO:0048568 [embryonic organ development]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0048663 [neuron fate commitment]
GO:0048839 [inner ear development]
GO:0048852 [diencephalon morphogenesis]
GO:0048863 [stem cell differentiation]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound]
GO:0050973 [detection of mechanical stimulus involved in equilibrioception]
GO:0060042 [retina morphogenesis in camera-type eye]
GO:0060235 [lens induction in camera-type eye]
GO:0060441 [epithelial tube branching involved in lung morphogenesis]
GO:0070848 [response to growth factor]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097150 [neuronal stem cell population maintenance]
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317 aa
34.3 kDa
No 0

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