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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

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Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

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Score

Score

Score

Antibodies

Column

 
 
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SOX2
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

SOX2

Gene description

SRY (sex determining region Y)-box 2

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (caudate, hypothalamus)
FANTOM5:Group enriched (brain, caudate, cerebellum, esophagus, hippocampus, pituitary gland, tonsil)

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in selected tissues, including CNS.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Cytoplasmic staining observed and disregarded.

Reliability score

Approved based on 1 antibody.
CAB010648
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Nasopharynx

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, esophagus, hippocampus, pituitary gland, tonsil)

GENE INFORMATION

Gene name

SOX2

Synonyms

Description

SRY (sex determining region Y)-box 2 (HGNC Symbol)

Entrez gene summary

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q26.33

Chromosome location (bp)

181711924 - 181714436

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000181449 (version 83.38)

Entrez gene

6657

UniProt

P48431 (UniProt - Evidence at protein level)

neXtProt

NX_P48431

Antibodypedia

SOX2 antibodies

PROTEIN BROWSER

SOX2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOX2-001
ENSP00000323588
ENST00000325404
P48431 [Direct mapping]
Transcription factor SOX-2
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Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001649 [osteoblast differentiation]
GO:0001654 [eye development]
GO:0001708 [cell fate specification]
GO:0001714 [endodermal cell fate specification]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007050 [cell cycle arrest]
GO:0007605 [sensory perception of sound]
GO:0009611 [response to wounding]
GO:0010033 [response to organic substance]
GO:0010468 [regulation of gene expression]
GO:0019827 [stem cell population maintenance]
GO:0021781 [glial cell fate commitment]
GO:0021879 [forebrain neuron differentiation]
GO:0021983 [pituitary gland development]
GO:0021984 [adenohypophysis development]
GO:0021987 [cerebral cortex development]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030539 [male genitalia development]
GO:0030858 [positive regulation of epithelial cell differentiation]
GO:0030900 [forebrain development]
GO:0030910 [olfactory placode formation]
GO:0031490 [chromatin DNA binding]
GO:0032526 [response to retinoic acid]
GO:0035019 [somatic stem cell population maintenance]
GO:0035198 [miRNA binding]
GO:0042246 [tissue regeneration]
GO:0042472 [inner ear morphogenesis]
GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043565 [sequence-specific DNA binding]
GO:0043586 [tongue development]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044798 [nuclear transcription factor complex]
GO:0045165 [cell fate commitment]
GO:0045596 [negative regulation of cell differentiation]
GO:0045597 [positive regulation of cell differentiation]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046148 [pigment biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0048286 [lung alveolus development]
GO:0048568 [embryonic organ development]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0048663 [neuron fate commitment]
GO:0048839 [inner ear development]
GO:0048852 [diencephalon morphogenesis]
GO:0048863 [stem cell differentiation]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound]
GO:0050973 [detection of mechanical stimulus involved in equilibrioception]
GO:0060042 [retina morphogenesis in camera-type eye]
GO:0060235 [lens induction in camera-type eye]
GO:0060441 [epithelial tube branching involved in lung morphogenesis]
GO:0070848 [response to growth factor]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097150 [neuronal stem cell population maintenance]
Show all
317 aa
34.3 kDa
No 0

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