Cell atlas - KCNIP1 - The Human Protein Atlas

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KCNIP1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	KCNIP1
Gene description	Kv channel interacting protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enriched (RPTEC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA066717
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (RPTEC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Vesicles (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA066717	A-431	Vesicles
	HPA066717	MCF7	Vesicles
	HPA066717	U-2 OS	Vesicles

GENE INFORMATION
Gene name	KCNIP1 (HGNC Symbol)
Synonyms	KCHIP1
Description	Kv channel interacting protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Chromosome	5
Cytoband	q35.1
Chromosome location (bp)	170353487 - 170736632
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182132 (version 83.38)
Entrez gene	30820
UniProt	Q9NZI2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NZI2
Antibodypedia	KCNIP1 antibodies

PROTEIN BROWSER

KCNIP1-001	KCNIP1-002	KCNIP1-003	KCNIP1-004	KCNIP1-005	KCNIP1-201	KCNIP1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNIP1-001 ENSP00000329686 ENST00000328939	A0A0C4DFQ7 [Direct mapping] Kv channel-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	216 aa 25.2 kDa	No	0
KCNIP1-002 ENSP00000431102 ENST00000520740	Q9NZI2 [Direct mapping] Kv channel-interacting protein 1 Show all	Predicted intracellular proteins Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005267 [potassium channel activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008076 [voltage-gated potassium channel complex] GO:0015459 [potassium channel regulator activity] GO:0030425 [dendrite] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0071805 [potassium ion transmembrane transport] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	188 aa 22.1 kDa	No	0
KCNIP1-003 ENSP00000414886 ENST00000434108	Q9NZI2 [Direct mapping] Kv channel-interacting protein 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005267 [potassium channel activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008076 [voltage-gated potassium channel complex] GO:0015459 [potassium channel regulator activity] GO:0030425 [dendrite] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0071805 [potassium ion transmembrane transport] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	241 aa 27.8 kDa	No	0
KCNIP1-004 ENSP00000395323 ENST00000411494	Q9NZI2 [Direct mapping] Kv channel-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005267 [potassium channel activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008076 [voltage-gated potassium channel complex] GO:0015459 [potassium channel regulator activity] GO:0030425 [dendrite] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0071805 [potassium ion transmembrane transport] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	227 aa 26.8 kDa	No	0
KCNIP1-005 ENSP00000366577 ENST00000377360	Q9NZI2 [Direct mapping] Kv channel-interacting protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005267 [potassium channel activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008076 [voltage-gated potassium channel complex] GO:0015459 [potassium channel regulator activity] GO:0030425 [dendrite] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0071805 [potassium ion transmembrane transport] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	225 aa 26.2 kDa	No	0
KCNIP1-201 ENSP00000375071 ENST00000390656	A0A0A0MS16 [Direct mapping] Kv channel-interacting protein 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] Show all	220 aa 25.5 kDa	No	0
KCNIP1-202 ENSP00000478151 ENST00000616807	A0A087WTU8 [Direct mapping] Kv channel-interacting protein 1 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] Show all	207 aa 24.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.