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KCNIP1

GENERAL INFORMATION

Gene name

 KCNIP1

Gene description

 Kv channel interacting protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enriched (RPTEC TERT1)
HPA (normal tissue):Tissue enhanced (cerebral cortex, epididymis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression mainly in CNS, gastrointestinal tract and heart muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA022864
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA022864

GENE INFORMATION

Gene name

 KCNIP1 (HGNC Symbol)

Synonyms

 KCHIP1

Description

 Kv channel interacting protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

Chromosome

 5

Cytoband

 q35.1

Chromosome location (bp)

 170353487 - 170736632

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182132 (version 83.38)

Entrez gene

 30820

UniProt

 Q9NZI2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZI2

Antibodypedia

 KCNIP1 antibodies

PROTEIN BROWSER
KCNIP1-001
KCNIP1-002
KCNIP1-003
KCNIP1-004
KCNIP1-005
KCNIP1-201
KCNIP1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNIP1-001
ENSP00000329686
ENST00000328939
A0A0C4DFQ7 [Direct mapping]
Kv channel-interacting protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0005509 [calcium ion binding]
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 216 aa
25.2 kDa 		No 0
KCNIP1-002
ENSP00000431102
ENST00000520740
Q9NZI2 [Direct mapping]
Kv channel-interacting protein 1
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Predicted intracellular proteins
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GO:0005244 [voltage-gated ion channel activity]
GO:0005267 [potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0030425 [dendrite]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0071805 [potassium ion transmembrane transport]
GO:1901379 [regulation of potassium ion transmembrane transport]
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 188 aa
22.1 kDa 		No 0
KCNIP1-003
ENSP00000414886
ENST00000434108
Q9NZI2 [Direct mapping]
Kv channel-interacting protein 1
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
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GO:0005244 [voltage-gated ion channel activity]
GO:0005267 [potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0030425 [dendrite]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0071805 [potassium ion transmembrane transport]
GO:1901379 [regulation of potassium ion transmembrane transport]
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 241 aa
27.8 kDa 		No 0
KCNIP1-004
ENSP00000395323
ENST00000411494
Q9NZI2 [Direct mapping]
Kv channel-interacting protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0005244 [voltage-gated ion channel activity]
GO:0005267 [potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0030425 [dendrite]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0071805 [potassium ion transmembrane transport]
GO:1901379 [regulation of potassium ion transmembrane transport]
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 227 aa
26.8 kDa 		No 0
KCNIP1-005
ENSP00000366577
ENST00000377360
Q9NZI2 [Direct mapping]
Kv channel-interacting protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005244 [voltage-gated ion channel activity]
GO:0005267 [potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0030425 [dendrite]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0071805 [potassium ion transmembrane transport]
GO:1901379 [regulation of potassium ion transmembrane transport]
Show all
 225 aa
26.2 kDa 		No 0
KCNIP1-201
ENSP00000375071
ENST00000390656
A0A0A0MS16 [Direct mapping]
Kv channel-interacting protein 1
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
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GO:0005509 [calcium ion binding]
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 220 aa
25.5 kDa 		No 0
KCNIP1-202
ENSP00000478151
ENST00000616807
A0A087WTU8 [Direct mapping]
Kv channel-interacting protein 1
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Predicted intracellular proteins
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GO:0005509 [calcium ion binding]
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 207 aa
24.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.