Cell atlas - LHFP - The Human Protein Atlas

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LHFP

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	LHFP
Gene description	Lipoma HMGIC fusion partner
Protein class	Cancer-related genes Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli.
RNA cell category	Cell line enhanced (AF22)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA058975
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli.

Main location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA058975	RH-30	Nucleoli
	HPA058975	U-2 OS	Nucleoli
	HPA058975	U-251 MG	Nucleoli

GENE INFORMATION
Gene name	LHFP (HGNC Symbol)
Synonyms	MGC22429
Description	Lipoma HMGIC fusion partner (HGNC Symbol)
Entrez gene summary	This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. This gene is fused to a high-mobility group gene in a translocation-associated lipoma. Mutations in another LHFP-like gene result in deafness in humans and mice. Alternatively spliced transcript variants have been found; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband
Chromosome location (bp)	39342892 - 39603528
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183722 (version 83.38)
Entrez gene	10186
UniProt	Q9Y693 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y693
Antibodypedia	LHFP antibodies

PROTEIN BROWSER

LHFP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LHFP-001 ENSP00000368908 ENST00000379589	Q9Y693 [Direct mapping] Lipoma HMGIC fusion partner A0A024RDR1 [Target identity:100%; Query identity:100%] Lipoma HMGIC fusion partner, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003677 [DNA binding] GO:0016021 [integral component of membrane] Show all	200 aa 21.6 kDa	Yes	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.