Expression of LHFP in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

LHFP

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LHFP
Gene description	Lipoma HMGIC fusion partner
Protein class	Cancer-related genes Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (AF22)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Widely distributed positivity in connective tissue.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA058975
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA058975

GENE INFORMATION
Gene name	LHFP (HGNC Symbol)
Synonyms	MGC22429
Description	Lipoma HMGIC fusion partner (HGNC Symbol)
Entrez gene summary	This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. This gene is fused to a high-mobility group gene in a translocation-associated lipoma. Mutations in another LHFP-like gene result in deafness in humans and mice. Alternatively spliced transcript variants have been found; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband
Chromosome location (bp)	39342892 - 39603528
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183722 (version 83.38)
Entrez gene	10186
UniProt	Q9Y693 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y693
Antibodypedia	LHFP antibodies

PROTEIN BROWSER

LHFP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LHFP-001 ENSP00000368908 ENST00000379589	Q9Y693 [Direct mapping] Lipoma HMGIC fusion partner A0A024RDR1 [Target identity:100%; Query identity:100%] Lipoma HMGIC fusion partner, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003677 [DNA binding] GO:0016021 [integral component of membrane] Show all	200 aa 21.6 kDa	Yes	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.