Cell atlas - FMNL1 - The Human Protein Atlas

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FMNL1

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	FMNL1
Gene description	Formin-like 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (Karpas-707, U-266/70)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA008129
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Karpas-707, U-266/70) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA008129	A-431	Cytosol
	HPA008129	U-2 OS	Cytosol
	HPA008129	U-251 MG	Cytosol

GENE INFORMATION
Gene name	FMNL1 (HGNC Symbol)
Synonyms	C17orf1, C17orf1B, FMNL
Description	Formin-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	45221444 - 45247320
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184922 (version 83.38)
Entrez gene	752
UniProt	O95466 (UniProt - Evidence at protein level)
neXtProt	NX_O95466
Antibodypedia	FMNL1 antibodies

PROTEIN BROWSER

FMNL1-001	FMNL1-006	FMNL1-007	FMNL1-010	FMNL1-011	FMNL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FMNL1-001 ENSP00000329219 ENST00000331495	O95466 [Direct mapping] Formin-like protein 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0003779 [actin binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005522 [profilin binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006929 [substrate-dependent cell migration] GO:0007264 [small GTPase mediated signal transduction] GO:0008360 [regulation of cell shape] GO:0009987 [cellular process] GO:0016020 [membrane] GO:0016043 [cellular component organization] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] GO:0030866 [cortical actin cytoskeleton organization] GO:0032059 [bleb] GO:0032794 [GTPase activating protein binding] GO:0045335 [phagocytic vesicle] GO:0048365 [Rac GTPase binding] GO:0051014 [actin filament severing] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] Show all	1100 aa 121.9 kDa	No	0
FMNL1-006 ENSP00000465474 ENST00000587489	K7EK60 [Direct mapping] Formin-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007010 [cytoskeleton organization] GO:0008360 [regulation of cell shape] Show all	682 aa 74.6 kDa	No	0
FMNL1-007 ENSP00000465137 ENST00000586643	K7EJE6 [Direct mapping] Formin-like protein 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007010 [cytoskeleton organization] GO:0008360 [regulation of cell shape] Show all	488 aa 55.1 kDa	No	0
FMNL1-010 ENSP00000466711 ENST00000589911	K7EMY8 [Direct mapping] Formin-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		127 aa 13.5 kDa	No	0
FMNL1-011 ENSP00000468301 ENST00000586092	K7ERL1 [Direct mapping] Formin-like protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0007010 [cytoskeleton organization] GO:0008360 [regulation of cell shape] GO:0016021 [integral component of membrane] Show all	152 aa 16.9 kDa	No	1
FMNL1-201 ENSP00000327442 ENST00000328118	A0A0A0MR62 [Direct mapping] Formin-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005488 [binding] GO:0007010 [cytoskeleton organization] GO:0008360 [regulation of cell shape] GO:0016043 [cellular component organization] Show all	626 aa 69.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.