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FMNL1

GENERAL INFORMATION

Gene name

 FMNL1

Gene description

 Formin-like 1

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in lymphoid tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 2 antibodies.
HPA008129 , HPA028288
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Appendix

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FMNL1 (HGNC Symbol)

Synonyms

 C17orf1, C17orf1B, FMNL

Description

 Formin-like 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 45221444 - 45247320

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184922 (version 83.38)

Entrez gene

 752

UniProt

 O95466 (UniProt - Evidence at protein level)

neXtProt

 NX_O95466

Antibodypedia

 FMNL1 antibodies

PROTEIN BROWSER
FMNL1-001
FMNL1-006
FMNL1-007
FMNL1-010
FMNL1-011
FMNL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FMNL1-001
ENSP00000329219
ENST00000331495
O95466 [Direct mapping]
Formin-like protein 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0003779 [actin binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006929 [substrate-dependent cell migration]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008360 [regulation of cell shape]
GO:0009987 [cellular process]
GO:0016020 [membrane]
GO:0016043 [cellular component organization]
GO:0017048 [Rho GTPase binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0032059 [bleb]
GO:0032794 [GTPase activating protein binding]
GO:0045335 [phagocytic vesicle]
GO:0048365 [Rac GTPase binding]
GO:0051014 [actin filament severing]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
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 1100 aa
121.9 kDa 		No 0
FMNL1-006
ENSP00000465474
ENST00000587489
K7EK60 [Direct mapping]
Formin-like protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
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 682 aa
74.6 kDa 		No 0
FMNL1-007
ENSP00000465137
ENST00000586643
K7EJE6 [Direct mapping]
Formin-like protein 1
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   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
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 488 aa
55.1 kDa 		No 0
FMNL1-010
ENSP00000466711
ENST00000589911
K7EMY8 [Direct mapping]
Formin-like protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 127 aa
13.5 kDa 		No 0
FMNL1-011
ENSP00000468301
ENST00000586092
K7ERL1 [Direct mapping]
Formin-like protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
GO:0016021 [integral component of membrane]
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 152 aa
16.9 kDa 		No 1
FMNL1-201
ENSP00000327442
ENST00000328118
A0A0A0MR62 [Direct mapping]
Formin-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005488 [binding]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
GO:0016043 [cellular component organization]
Show all
 626 aa
69.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.