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Strong cytoplasmic staining in malignant lymphomas. strong staining was also seen in lymphoid cells in tumor stroma. Single cases of urothelial tumors showed weak to moderate immunoreactivity. Virtually no staining in other malignancies.
Lymphomas showed distinct nuclear and cytoplasmic staining, except Hodgkin's disease which were negative. Remaining tumor tissues were negative.
GENE INFORMATION
Gene name
FMNL1 (HGNC Symbol)
Synonyms
C17orf1, C17orf1B, FMNL
Description
Formin-like 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]