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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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FMNL1
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

FMNL1

Gene description

Formin-like 1

Protein class

Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (Karpas-707, U-266/70)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

Supported based on 2 antibodies.
HPA008129 , HPA028288
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA008129
HPA028288

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Strong cytoplasmic staining in malignant lymphomas. strong staining was also seen in lymphoid cells in tumor stroma. Single cases of urothelial tumors showed weak to moderate immunoreactivity. Virtually no staining in other malignancies.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Lymphomas showed distinct nuclear and cytoplasmic staining, except Hodgkin's disease which were negative. Remaining tumor tissues were negative.

GENE INFORMATION

Gene name

FMNL1 (HGNC Symbol)

Synonyms

C17orf1, C17orf1B, FMNL

Description

Formin-like 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q21.31

Chromosome location (bp)

45221444 - 45247320

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000184922 (version 83.38)

Entrez gene

752

UniProt

O95466 (UniProt - Evidence at protein level)

neXtProt

NX_O95466

Antibodypedia

FMNL1 antibodies

PROTEIN BROWSER

FMNL1-001
FMNL1-006
FMNL1-007
FMNL1-010
FMNL1-011
FMNL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FMNL1-001
ENSP00000329219
ENST00000331495
O95466 [Direct mapping]
Formin-like protein 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0003779 [actin binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006929 [substrate-dependent cell migration]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008360 [regulation of cell shape]
GO:0009987 [cellular process]
GO:0016020 [membrane]
GO:0016043 [cellular component organization]
GO:0017048 [Rho GTPase binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0032059 [bleb]
GO:0032794 [GTPase activating protein binding]
GO:0045335 [phagocytic vesicle]
GO:0048365 [Rac GTPase binding]
GO:0051014 [actin filament severing]
GO:0051015 [actin filament binding]
GO:0070062 [extracellular exosome]
Show all
1100 aa
121.9 kDa
No 0
FMNL1-006
ENSP00000465474
ENST00000587489
K7EK60 [Direct mapping]
Formin-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
Show all
682 aa
74.6 kDa
No 0
FMNL1-007
ENSP00000465137
ENST00000586643
K7EJE6 [Direct mapping]
Formin-like protein 1
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
Show all
488 aa
55.1 kDa
No 0
FMNL1-010
ENSP00000466711
ENST00000589911
K7EMY8 [Direct mapping]
Formin-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
127 aa
13.5 kDa
No 0
FMNL1-011
ENSP00000468301
ENST00000586092
K7ERL1 [Direct mapping]
Formin-like protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
GO:0016021 [integral component of membrane]
Show all
152 aa
16.9 kDa
No 1
FMNL1-201
ENSP00000327442
ENST00000328118
A0A0A0MR62 [Direct mapping]
Formin-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005488 [binding]
GO:0007010 [cytoskeleton organization]
GO:0008360 [regulation of cell shape]
GO:0016043 [cellular component organization]
Show all
626 aa
69.5 kDa
No 0

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