Expression of KRT5 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KRT5
Gene description	Keratin 5, type II
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Group enriched (HaCaT, hTCEpi)
HPA (normal tissue):	Group enriched (esophagus, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Specific cytoplasmic and membranous expression in squamous and respiratory epithelia as well as glandular cells of male genitalia and breast.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA059479 , CAB000027 , CAB000129
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA059479	CAB000027	CAB000129

GENE INFORMATION
Gene name	KRT5 (HGNC Symbol)
Synonyms	EBS2, KRT5A
Description	Keratin 5, type II (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	52514575 - 52520687
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186081 (version 83.38)
Entrez gene	3852
UniProt	P13647 (UniProt - Evidence at protein level)
neXtProt	NX_P13647
Antibodypedia	KRT5 antibodies

PROTEIN BROWSER

KRT5-001	KRT5-003	KRT5-004	KRT5-005	KRT5-007	KRT5-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT5-001 ENSP00000252242 ENST00000252242	P13647 [Direct mapping] Keratin, type II cytoskeletal 5 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005882 [intermediate filament] GO:0005886 [plasma membrane] GO:0008544 [epidermis development] GO:0016020 [membrane] GO:0031581 [hemidesmosome assembly] GO:0034329 [cell junction assembly] GO:0045095 [keratin filament] GO:0070062 [extracellular exosome] GO:0097110 [scaffold protein binding] Show all	590 aa 62.4 kDa	No	0
KRT5-003 ENSP00000449651 ENST00000546577	F8VV57 [Direct mapping] Keratin, type II cytoskeletal 5 Show all	TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		132 aa 12.2 kDa	No	0
KRT5-004 ENSP00000448041 ENST00000551275	F8VU69 [Direct mapping] Keratin, type II cytoskeletal 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	147 aa 14.3 kDa	No	0
KRT5-005 ENSP00000447209 ENST00000549420	F8W0C6 [Direct mapping] Keratin, type II cytoskeletal 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] GO:0045095 [keratin filament] Show all	179 aa 20.7 kDa	No	0
KRT5-007 ENSP00000449783 ENST00000551188	H0YIN9 [Direct mapping] Keratin, type II cytoskeletal 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] GO:0045095 [keratin filament] Show all	196 aa 21.9 kDa	No	0
KRT5-008 ENSP00000448767 ENST00000548409	H0YI76 [Direct mapping] Keratin, type II cytoskeletal 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] GO:0045095 [keratin filament] Show all	201 aa 23 kDa	No	0