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KRT5

GENERAL INFORMATION

Gene name

 KRT5

Gene description

 Keratin 5, type II

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (esophagus, skin)
GTEx:Expressed in all
FANTOM5:Group enriched (cervix, uterine, esophagus, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Specific cytoplasmic and membranous expression in squamous and respiratory epithelia as well as glandular cells of male genitalia and breast.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA059479 , CAB000027 , CAB000129
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, esophagus, tonsil)

GENE INFORMATION

Gene name

 KRT5 (HGNC Symbol)

Synonyms

 EBS2, KRT5A

Description

 Keratin 5, type II (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 52514575 - 52520687

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186081 (version 83.38)

Entrez gene

 3852

UniProt

 P13647 (UniProt - Evidence at protein level)

neXtProt

 NX_P13647

Antibodypedia

 KRT5 antibodies

PROTEIN BROWSER
KRT5-001
KRT5-003
KRT5-004
KRT5-005
KRT5-007
KRT5-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT5-001
ENSP00000252242
ENST00000252242
P13647 [Direct mapping]
Keratin, type II cytoskeletal 5
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005882 [intermediate filament]
GO:0005886 [plasma membrane]
GO:0008544 [epidermis development]
GO:0016020 [membrane]
GO:0031581 [hemidesmosome assembly]
GO:0034329 [cell junction assembly]
GO:0045095 [keratin filament]
GO:0070062 [extracellular exosome]
GO:0097110 [scaffold protein binding]
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 590 aa
62.4 kDa 		No 0
KRT5-003
ENSP00000449651
ENST00000546577
F8VV57 [Direct mapping]
Keratin, type II cytoskeletal 5
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   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 132 aa
12.2 kDa 		No 0
KRT5-004
ENSP00000448041
ENST00000551275
F8VU69 [Direct mapping]
Keratin, type II cytoskeletal 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
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 147 aa
14.3 kDa 		No 0
KRT5-005
ENSP00000447209
ENST00000549420
F8W0C6 [Direct mapping]
Keratin, type II cytoskeletal 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
GO:0045095 [keratin filament]
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 179 aa
20.7 kDa 		No 0
KRT5-007
ENSP00000449783
ENST00000551188
H0YIN9 [Direct mapping]
Keratin, type II cytoskeletal 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
GO:0045095 [keratin filament]
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 196 aa
21.9 kDa 		No 0
KRT5-008
ENSP00000448767
ENST00000548409
H0YI76 [Direct mapping]
Keratin, type II cytoskeletal 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
GO:0045095 [keratin filament]
Show all
 201 aa
23 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.